Multifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluation

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dc.authorscopusid59274881700
dc.authorscopusid58304421000
dc.authorscopusid57222400961
dc.authorscopusid57729446700
dc.authorscopusid57207305790
dc.authorscopusid56491067300
dc.authorscopusid58511890200
dc.contributor.authorDeveci, Mehmet Zeki Yilmaz
dc.contributor.authorEnguven, Gozde
dc.contributor.authorEge, Hasan
dc.contributor.authorAlakus, Ibrahim
dc.contributor.authorAgturk, Gokhan
dc.contributor.authorYontem, Fulya Dal
dc.contributor.authorYilmaz, Senanur
dc.date.accessioned2024-09-19T15:41:20Z
dc.date.available2024-09-19T15:41:20Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIncisional hernia, a prevalent postoperative complication, is characterized by the protrusion of organs or tissues through damaged abdominal wall. Predisposing factors for hernias include obesity, wound infections, immunosuppression, and comorbidities. However, hernia patches currently in use, including the commercial polypropylene (PP) patch, still have limitations in providing the mechanical and biological properties necessary for abdominal wall regeneration. In this study, three dimensional (3D) printing and coaxial electrospinning methods were combined to create a multifunctional double layered hernia repair biopatch to overcome these limitations. The double-layer design of the biopatch serves a multifunctional role in addressing incisional hernia models, with 3D printed ciprofloxacin (CIP) loaded polycaprolactone (PCL)/gelatin (Ge) scaffold (3DCIP) layer and coaxially electrospun PCL/Ge/?-carrageenan (?-C) nanofiber (NF) layers. While 3DCIP layers provides temporary mechanical reinforcement to the damaged abdominal wall, prevention of adhesions to internal organs, and reduction of surgical site infections, NF layer serves as tissue regeneration and fast wound healing. The developed multifunctional hernia biopatches underwent comprehensive physical and chemical characterization, followed by in vitro and in vivo evaluations. These evaluations included comparisons with a commercial PP patch, which was used as the control in the experiments. The study successfully fabricated multifunctional hernia biopatches with excellent antibacterial properties, high mechanical robustness, and strong biocompatibility. © 2024 Elsevier B.V.en_US
dc.description.sponsorshipCanadian Institute of Planners, CIP, (76,77); Hatay Mustafa Kemal University, (GAP.002)en_US
dc.identifier.doi10.1016/j.jddst.2024.106132
dc.identifier.issn1773-2247
dc.identifier.scopus2-s2.0-85202784685en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2024.106132
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14192
dc.identifier.volume100en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEditions de Santeen_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3D printingen_US
dc.subjectBiopatchen_US
dc.subjectCiprofloxacinen_US
dc.subjectControlled releaseen_US
dc.subjectElectrospinningen_US
dc.subjectHernia repairen_US
dc.titleMultifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluationen_US
dc.typeArticleen_US

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