Antiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2

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dc.authoridAllahverdiyev, Adil M./0000-0002-7031-5986
dc.contributor.authorAllahverdiyev, A
dc.contributor.authorDuran, N
dc.contributor.authorOzguven, M
dc.contributor.authorKoltas, S
dc.date.accessioned2024-09-18T20:29:50Z
dc.date.available2024-09-18T20:29:50Z
dc.date.issued2004
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractMelissa officinalis L. (Lamiaceae) has been used in a variety of practical applications in medical science. Our objective in the current study was to determine the effects of the volatile oil components of M. officinalis on Herpes simplex virus type 2 (HSV-2) replication in HEp-2 cells. Four different concentrations (25, 50, 100, 150 and 200 mug/ml) of volatile oils were examined. Experiments were carried out using HEp-2 cells. M. officinalis volatile oil was found to be non-toxic to HEp-2 cells up to a concentration of 100 mug/ml. It was, however, found to be slightly toxic at a concentration over of 100 mug/ml. The antiviral activity of non-toxic concentrations against HSV-2 was tested. The replication of HSV-2 was inhibited, indicating that the M. officinalis L. extract contains an anti-HSV-2 substance. (C) 2004 Elsevier GrnbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.phymed.2003.07.014
dc.identifier.endpage661en_US
dc.identifier.issn0944-7113
dc.identifier.issue7-8en_US
dc.identifier.pmid15636181en_US
dc.identifier.scopus2-s2.0-10844267617en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage657en_US
dc.identifier.urihttps://doi.org/10.1016/j.phymed.2003.07.014
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11083
dc.identifier.volume11en_US
dc.identifier.wosWOS:000226315400014en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofPhytomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelissa officinalis L.en_US
dc.subjectHEp-2 cellsen_US
dc.subjectantiviral activityen_US
dc.subjectTCID50 valueen_US
dc.subjectcytotoxicityen_US
dc.titleAntiviral activity of the volatile oils of Melissa officinalis L. against Herpes simplex virus type-2en_US
dc.typeArticleen_US

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