Expression of cyclooxygenase-2 and its relation to histological grade, inducible nitric oxide synthase, matrix metalloproteinase-2, CD-34, Caspase-3, and CD8 in invasive ductal carcinoma of the breast

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dc.authoridAban, Nedim/0009-0009-9204-7810
dc.contributor.authorAtik, Esin
dc.contributor.authorAkansu, Bulent
dc.contributor.authorBakaris, Sevgi
dc.contributor.authorAban, Nedim
dc.date.accessioned2024-09-18T21:07:41Z
dc.date.available2024-09-18T21:07:41Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: To assess by immunohistochemistry the cyclooxygenase-2 (COX-2) expression in invasive ductal carcinoma and its possible correlation with the histological grade, inducible nitric oxide synthase (iNOS), matrix metalloproteinase-2 (MMP2), and other common immunohistochemical parameters (CD-34, Caspase-3, and CD8). Methods: This was a retrospective pathology archive study including 50 female patients and was performed in Mustafa Kemal University, Hatay, and Sutcu Imam University, Kahraman Maras, Turkey. The routine hematoxylin-eosin staining and COX-2, iNOS, MMP-2, CD-34, CASP-3, and CD8 immunoperoxidase techniques were performed on paraffin-embedded tissues. Results: The mean value of COX-2 was 274.02 +/- 54.49 and MMP-2 was 263.42 +/- 54.30, whereas the mean iNOS values were 258.10 +/- 56.05. CD-34 staining also yielded positive results as 26.18 +/- 8.00. The mean value of CASP-3 was 284.06 +/- 41.2 and CD8 was 164.17 +/- 69.5. This reveals an inverse correlation between CASP-3 reactivity and CD8 (Spearman correlation [r]= -0.33, p=0.01). There was also an inverse correlation between iNOS reactivity and patients age (r = -0.29, p=0.03). There was a positive correlation with COX-2 and MMP-2 (p=0.00), but there was no relation with COX-2 and other parameters. Conclusion: COX-2 expression is an important parameter for invasive ductal carcinoma of the breast. We found a positive correlation between COX-2 and MMP-2, whereas, we could not show direct correlation between COX-2 and iNOS, CD-34, CASP-3, and CD8.en_US
dc.identifier.endpage134en_US
dc.identifier.issn0379-5284
dc.identifier.issue2en_US
dc.identifier.pmid20174726en_US
dc.identifier.scopus2-s2.0-77949502442en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage130en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13840
dc.identifier.volume31en_US
dc.identifier.wosWOS:000276937100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIn-Situen_US
dc.subjectMolecular Markersen_US
dc.subjectGrowth-Factoren_US
dc.subjectCancer Cellsen_US
dc.subjectMmp-2en_US
dc.subjectAngiogenesisen_US
dc.subjectMetastasisen_US
dc.subjectHer-2/Neuen_US
dc.subjectPhenotypeen_US
dc.subjectApoptosisen_US
dc.titleExpression of cyclooxygenase-2 and its relation to histological grade, inducible nitric oxide synthase, matrix metalloproteinase-2, CD-34, Caspase-3, and CD8 in invasive ductal carcinoma of the breasten_US
dc.typeArticleen_US

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