Nobiletin alleviates methotrexate-induced hepatorenal toxicity in rats

Basit Öğe Kaydı
dc.authoridKazak, Filiz/0000-0002-9065-394X
dc.contributor.authorKazak, Filiz
dc.contributor.authorUyar, Ahmet
dc.contributor.authorCoskun, Pinar
dc.contributor.authorYaman, Turan
dc.date.accessioned2024-09-18T20:14:59Z
dc.date.available2024-09-18T20:14:59Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWe investigated the possible ameliorative effects of nobiletin (NBL) against methotrexate (MTX)-induced hepatorenal toxicity in rats. Twenty-eight Wistar albino rats were randomly divided into four groups, namely: Control; MTX (administered 20 mg/kg MTX); MTX+NBL (administered 20 mg/kg MTX and 10 mg/kg NBL per day); and NBL (administered 10 mg/kg/day NBL). Histopathological, immunohistochemical and biochemical analyses were performed on the kidney and liver tissues of rats at the end of the study. MTX caused renal toxicity, as indicated by increases in malondialdehyde (MDA) and caspase-3, as well as decreases in reduced glutathione (GSH), glucose-6-phosphate dehydrogenase (G6PD), glutathione peroxidase (GPx), catalase (CAT) and B-cell lymphoma-2 (Bcl-2). MTX also caused hepatotoxicity, as indicated by increases in 8-hydroxy-2'-deoxyguanosine (8-OHdG), tumor necrosis factor alpha (TNF-alpha), MDA and caspase-3 and decrease in interleukin 10 (IL-10), GSH, total antioxidant capacity, GPx, G6PD, CAT and Bcl-2. MTX caused histopathological changes in kidney and liver tissues indicating tissue and cellular damage. Administration of NBL concurrently with methotrexate reduced oxidative stress, inflammatory and apoptotic signs, and prevented kidney and liver damage caused by methotrexate. We consider NBL has attenuating and ameliorating effects on methotrexate-induced hepatorenal toxicity.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Research Fund [056, IHSLC 2021]; Hatay Mustafa Kemal University Research Funden_US
dc.description.sponsorshipThis study was supported by Hatay Mustafa Kemal University Research Fund (18.M.056). The abstract of this study was presented in the 4th International Health Science and Life Congress (IHSLC 2021), 8-10 April 2021.en_US
dc.identifier.doi10.1080/10520295.2024.2335168
dc.identifier.endpage146en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid38563051en_US
dc.identifier.scopus2-s2.0-85189882156en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2024.2335168
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9357
dc.identifier.volume99en_US
dc.identifier.wosWOS:001195741000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytokineen_US
dc.subjecthepatorenal toxicityen_US
dc.subjectmethotrexateen_US
dc.subjectnobiletinen_US
dc.subjectoxidative stressen_US
dc.titleNobiletin alleviates methotrexate-induced hepatorenal toxicity in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu