Histopathologic Evaluation of Neurovascular Bundles and Periprostatic Tissue in Interfascial and Intrafascial Nerve-sparing Radical Prostatectomy Technique: A Cadaveric Anatomic Study

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dc.contributor.authorRifaioglu, Murat M.
dc.contributor.authorDavarci, Mursel
dc.contributor.authorOzgur, Tumay
dc.contributor.authorOzkanli, Seyma
dc.contributor.authorOzdes, Taskin
dc.contributor.authorInci, Mehmet
dc.contributor.authorOnem, Kadir
dc.date.accessioned2024-09-18T21:03:12Z
dc.date.available2024-09-18T21:03:12Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE To compare interfascial (IEF) or intrafascial (IAF) periprostatic nerve dissection technique in prostate tissue using immunohistochemical methods in fresh cadavers. MATERIALS AND METHODS Prostate tissues of 25 fresh cadavers were removed from rectum and other surrounding structures. IEF nerve dissection (n - 25) was performed on the right and IAF nerve (n - 25) dissection on the left side of each prostate under direct visualization. The base, center, and apex of each prostate lobes and fascia dissected were sampled for blind histopathologic evaluation. Total counts of nerve, artery, and vein were performed on hematoxylin and eosin stained sections, whereas sympathetic and parasympathetic nerve counts were performed on immunohistochemical stained sections. Iatrogenic surgical margin injury at base, center, and apex detected were compared between groups. RESULTS Thickness of neurovascular bundle dissected in IAF was found significantly higher than IEF technique. The number of residual sympathetic fibers after dissection of neurovascular bundle was found significantly higher in IAF group. There were significant decreases in total nerve, parasympathetic, and sympathetic nerve counts only at the central region of prostate in IAF group. A significant decrease was found in the number of residual vein left in the fascia only at the apex by IAF dissection. Of surgical margin injury results, no significant difference was detected between IAF and IEF groups at any location. CONCLUSION IAF provides better preservation of sympathetic but not parasympathetic fibers without increasing surgical injury of prostate capsule. (C) 2013 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.urology.2013.06.012
dc.identifier.endpage954en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue4en_US
dc.identifier.pmid23910560en_US
dc.identifier.scopus2-s2.0-84884986173en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage948en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2013.06.012
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13297
dc.identifier.volume82en_US
dc.identifier.wosWOS:000324994000053en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPositive Surgical Marginsen_US
dc.subjectErectile Functionen_US
dc.subjectPreservationen_US
dc.subjectPotencyen_US
dc.titleHistopathologic Evaluation of Neurovascular Bundles and Periprostatic Tissue in Interfascial and Intrafascial Nerve-sparing Radical Prostatectomy Technique: A Cadaveric Anatomic Studyen_US
dc.typeArticleen_US

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