Protective effects of minocycline on experimental spinal cord injury in rats

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dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridYILMAZ, Atilla/0000-0002-1081-3545
dc.contributor.authorAras, Mustafa
dc.contributor.authorAltas, Murat
dc.contributor.authorMotor, Sedat
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorYilmaz, Atilla
dc.contributor.authorOzgiray, Erkin
dc.contributor.authorSeraslan, Yurdal
dc.date.accessioned2024-09-18T20:59:05Z
dc.date.available2024-09-18T20:59:05Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: The effects of minocycline on neuronal injury after spinal cord injury (SCI) are limited and controversial. Therefore we aimed to investigate the protective effects of minocycline on tissue and on serum concentrations of malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) activity, tissue total antioxidant and oxidant status (TAS and TOS, respectively), and AST and LDH levels in rats with SCI. Methods: This study was performed on 7-8 weeks 38 male Wistar albino rats. The animals were randomly divided into five groups: group 1, Sham (n = 8); group 2, SCI (spinal cord injury)/control (n = 8); group 3, SCI + minocycline3 (n = 7); group 4, SCI + minocycline30 (n = 8) and group 5 SCI + minocycline90 (n = 7). Blood and tissue samples were analysed for MDA, SOD, GSH-Px, TAS, TOS, AST and LDH levels. Results: The MDA levels were significantly higher in SCI group compared to sham group (p < 0.001), and MDA levels were also significantly higher in SCI group compared to SCI + M-3, SCI + M-30, SCI + M-90 (p < 0.05). SOD levels were significantly higher in SCI + M-30 when compared to SCI and SCI + M-3 groups (p < 0.05). GSH-Px levels decreased significantly in SCI and SCI + M-3 groups compared to sham (p < 0.05). SCI + M-3 group showed significantly decreased levels of TAS and TOS compared to SCI group (p < 0.05). TAS and TOS levels significantly increased in SCI + M-90 group compared to SCI + M-3 and SCI + M-30 groups (p < 0.05). Conclusions: The present study demonstrates the dose-dependent antioxidant activity of minocycline against spinal cord injury in rats. Minocycline administration increased antioxidant enzyme levels and improved total antioxidant status. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.injury.2015.05.018
dc.identifier.endpage1474en_US
dc.identifier.issn0020-1383
dc.identifier.issn1879-0267
dc.identifier.issue8en_US
dc.identifier.pmid26052053en_US
dc.identifier.scopus2-s2.0-84937521336en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1471en_US
dc.identifier.urihttps://doi.org/10.1016/j.injury.2015.05.018
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12350
dc.identifier.volume46en_US
dc.identifier.wosWOS:000361894200008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofInjury-International Journal of The Care of The Injureden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpinal cord injuryen_US
dc.subjectMinocyclineen_US
dc.subjectAntioxidant activityen_US
dc.subjectExperimental studyen_US
dc.titleProtective effects of minocycline on experimental spinal cord injury in ratsen_US
dc.typeArticleen_US

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