Protective and therapeutic effects of nobiletin against cisplatin-induced nephrotoxicity in rats

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dc.authoridKazak, Filiz/0000-0002-9065-394X
dc.contributor.authorKazak, Filiz
dc.contributor.authorCoskun, Pinar
dc.contributor.authorYarim, Gul Fatma
dc.contributor.authorBaspinar, Nuri
dc.contributor.authorOzdemir, Ozgur
dc.contributor.authorAtes, Mehmet Burak
dc.contributor.authorAltug, Muhammed Enes
dc.date.accessioned2024-09-18T20:11:27Z
dc.date.available2024-09-18T20:11:27Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPossible protective and therapeutic effects of nobiletin on kidney in a cisplatin-induced nephrotoxicity rat model were investigated. Forty male albino rats were divided into four groups: control, cisplatin (CIS), cisplatin+nobiletin (CIS+NOB), and nobiletin+cisplatin (NOB+CIS). At the end of the study, the rats were subjected to biochemical, histological and immunohistochemical analyzes. Compared to the control group, tGSH (p < 0.05) levels, and G6PD (p < 0.05) and GPx (p < 0.001) activities, were increased in the CIS group; while significant (p < 0.05) decreases occurred in the MDA and TOC levels. Histopathologically, the kidneys of the groups administered nobiletin (CIS+NOB, NOB+CIS) were significantly different from the CIS group, being closer to control group in terms of degeneration and hyaline cylinder formation in the tubules (p < 0.05). While dilatation in the tubules, protein-rich fluid and hyaline cylinder formation in the lumen were most common in the CIS group, a significant decrease (p < 0.05) of these parameters was seen in the nobiletin groups (CIS+NOB, NOB+CIS). This study suggests that nobiletin can be effective in preventing and ameliorating toxic effects of cisplatin on the kidney.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Research Fund [18.M.023]en_US
dc.description.sponsorshipThe work was supported by the Hatay Mustafa Kemal University Research Fund [18.M.023].en_US
dc.identifier.doi10.1080/10520295.2024.2380663
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.pmid38563051en_US
dc.identifier.scopus2-s2.0-85200235208en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2024.2380663
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8864
dc.identifier.wosWOS:001283400800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectG6PDen_US
dc.subjecthistopathological changesen_US
dc.subjectkidneyen_US
dc.subjectnobiletinen_US
dc.titleProtective and therapeutic effects of nobiletin against cisplatin-induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

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