The protective effect of Boswellic acid and Ellagic acid loaded, colon targeted, and pH-sensitive N-succinyl chitosan in ulcerative colitis rat model

Basit Öğe Kaydı
dc.authoridAltinok-Yipel, Fulya/0000-0001-8577-2031
dc.authoridAslan, Abdullah/0000-0002-6243-4221
dc.authoridTekeli, Ibrahim Ozan/0000-0002-6845-2279
dc.authoridYipel, Mustafa/0000-0002-6390-9313
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.contributor.authorYipel, Mustafa
dc.contributor.authorTekeli, Ibrahim Ozan
dc.contributor.authorAltinok-Yipel, Fulya
dc.contributor.authorCoskun, Pinar
dc.contributor.authorAslan, Abdullah
dc.contributor.authorGuvenc, Mehmet
dc.contributor.authorBeyazit, Neslihan
dc.date.accessioned2024-09-18T20:11:36Z
dc.date.available2024-09-18T20:11:36Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTargeted drug delivery systems that provide therapeutic activity with lower concentrations of both herbal and other substances, while reducing access to non-target sites and undesirable effects; have an important potential for future projections in terms of pharmacological and toxicological studies. The present study aimed to investigate the protective effects of Acetyl 11-keto-beta-boswellic acid (AKBA) and Ellagic acid (EA) loaded, colon targeted, and pH-Sensitive N-succinyl chitosans (NsCh) in ulcerative colitis (UC) model induced by acetic acid (AA) in rats. The physicochemical characterization (elemental analysis, FT-IR, DSC, XRD, SEM, NMR) analyses, swelling, and releasing tests of NsCh's suggested that AKBA and EA were successfully loaded to pH-sensitive polymer and targeted to the colon. The targeted AKBA and EA were administered to Wistar rats (n:30, 5 groups) and damage, inflammatory cytokine, protein expression, oxidative stress, and antioxidant parameter levels in colon tissues of the groups were determined. Increase in the levels of CAT, GPx activities, and decrease in necrosis, inflammation, and levels of MDA, TNF-alpha, COX-2, NF-kB were observed in the targeted EA and AKBA groups compared to the UC group. The potential protective effect of EA and AKBA loaded, colon-targeted, pH sensitive controlled releasing system against UC and the potential to be licensed preparations by completing the next stages of in vitro and in vivo studies were demonstrated.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [215O891]en_US
dc.description.sponsorshipAcknowledgements This study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) (Project number: 215O891) .en_US
dc.identifier.doi10.1016/j.jddst.2021.103023
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85122096257en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2021.103023
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8971
dc.identifier.volume68en_US
dc.identifier.wosWOS:000788092100003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColon targetingen_US
dc.subject11-Keto-? -boswellic aciden_US
dc.subjectEllagic aciden_US
dc.subjectN-Succinyl chitosanen_US
dc.subjectUlcerative colitisen_US
dc.titleThe protective effect of Boswellic acid and Ellagic acid loaded, colon targeted, and pH-sensitive N-succinyl chitosan in ulcerative colitis rat modelen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
6.83 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu