Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns

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dc.authoridOzgocmen, Salih/0000-0002-4860-452X
dc.contributor.authorOzgocmen, S
dc.contributor.authorOzyurt, H
dc.contributor.authorSogut, S
dc.contributor.authorAkyol, O
dc.contributor.authorArdicoglu, O
dc.contributor.authorYildizhan, H
dc.date.accessioned2024-09-18T20:20:07Z
dc.date.available2024-09-18T20:20:07Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWe proposed to assess the oxidant/antioxidant status, lipid peroxidation and nitric oxide (NO) in untreated fibromyalgia (FM) patients and controls. The effect of amitriptyline (A, 20 mg daily) and sertraline (S, 100 mg daily) treatment on patients' superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (ADA) enzyme activities, thiobarbituric acid reactive substances (TBARS) and NO levels was investigated. Thirty female patients with primary FM and age-matched 16 healthy female controls were included. Patients received an 8-week course of treatment with either A or S. FM patients had higher serum levels of TBARS (particularly malondialdehyde) and lower levels of nitrite compared to controls whereas enzyme activities were similar. A and S significantly improved Fibromyalgia Impact Questionnaire (FIQ) pain scores, Hamilton anxiety and depression rating scales. But neither A nor S had significant effects on measured oxidative stress parameters, except SOD activity that was significantly reduced after S treatment. Total myalgic scores negatively correlated with XO activity, and depression scales negatively correlated with levels of TBARS. Our results indicate that patients with FM are under oxidative stress. These findings represent a rationale for further research assessing the effect of free radical scavengers or antioxidant agents like vitamins and omega-3 fatty acids on peripheral and central mechanisms in FM.en_US
dc.identifier.doi10.1007/s00296-005-0079-y
dc.identifier.endpage603en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue7en_US
dc.identifier.pmid16283318en_US
dc.identifier.scopus2-s2.0-33645847273en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage598en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-005-0079-y
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10060
dc.identifier.volume26en_US
dc.identifier.wosWOS:000236781100002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfibromyalgiaen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectlipid peroxidationen_US
dc.subjectnitric oxideen_US
dc.subjectoxidative stressen_US
dc.titleAntioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concernsen_US
dc.typeArticleen_US

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