ANTIMONY INDUCED GLUTATHIONE EFFLUX FROM HUMAN ERYTHROCTES

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dc.contributor.authorSahilli, Yeliz Cakir
dc.contributor.authorAkgun, Mehmet Hanifi
dc.contributor.authorYildiz, Deniz
dc.date.accessioned2024-09-18T19:54:34Z
dc.date.available2024-09-18T19:54:34Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractAntimony is a trace element which has wide variety of industrial application. Antimony has recently been considered as an environmental pollutant. Among the inorganic forms, SbIII is the more toxic form. SbIII is ten times more toxic compared to the SbV. Consuming plants that are grown in antimony contaminated soil is one of the way by which humans are exposed to antimony. AsIII and SbIII forms strong bonds with free-SH groups. When SbIII or SbV interacts with proteins that contain free-SH groups, protein inactivation usually results in. Antimony may also result in free radical generation and induction of oxidative stress. Even though antimony has some applications in health as a drug, its biological effects have not been investigated in detail. In the present study we investigated the effects of SbIII on glutathione efflux in human erythrocytes. The effects of N-acetyl-L-cysteine on antimony induced glutathione oxidation and glutathione efflux were also investigated. Extracellular glutathione concentration significantly increased and reached to 0.033 +/- 0.0034 micromole/ml erythrocyte with 1 mM of potassium antimony tartrate in four hours. The control value of extracellular glutathione was 0.020 +/- 0.0035 micromole/ml erythrocyte. Our results show that SbIII treatment of erythrocyte results in glutathione efflux.en_US
dc.identifier.endpage4971en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue11en_US
dc.identifier.startpage4965en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7805
dc.identifier.volume25en_US
dc.identifier.wosWOS:000390641900060en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimonyen_US
dc.subjectN-acetyl-L-cysteineen_US
dc.subjectGlutathioneen_US
dc.subjectErythrocyteen_US
dc.titleANTIMONY INDUCED GLUTATHIONE EFFLUX FROM HUMAN ERYTHROCTESen_US
dc.typeArticleen_US

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