The effect of dexpanthenol on experimentally induced ovarian ischaemia/reperfusion injury: a biochemical and histopathological evaluation

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dc.contributor.authorKarapinar, Oya Soylu
dc.contributor.authorPinar, Neslihan
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorDogan, Esin Atik
dc.contributor.authorBayraktar, Suphi
dc.contributor.authorSahin, Hanifi
dc.contributor.authorDolapcioglu, Kenan
dc.date.accessioned2024-09-18T20:53:01Z
dc.date.available2024-09-18T20:53:01Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effect of two different doses of dexpanthenol (Dxp) onexperimentally induced ovarian ischaemia/reperfusion (I/R) injury ina rat model. Forty female rats were randomly divided into fivegroups: Group 1: sham operation; Group 2: 3-h ischaemia; Groups 3: 3-h ischaemia, 3-h reperfusion (I/R); Group 4: I/R + 300 mg/kg Dxp intraperitoneally (i.p) Group 5: I /R + 500 mg/kg Dxpi.p. Total anti-oxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), tissue malondialdehyde (MDA) and activities of glutathione peroxidase and catalase were calculated. Ovarian tissue damage was assessed using a histopathological scoring system. The TOS and OSI values were significantly lower in Group 5, as compared to Groups 2 and 3 (p < 0.05). The MDA levels in Group 1 and Group 5 were significantly lower than those in Group 3 (p < 0.05). CAT and GSH-Px activity was higher in Group 5 than in Group 2 and Group 3 (p = 0.00). Tissue damage scores were elevated in all the groups compared with sham group, but the treatment with the different doses of Dxp before reperfusion ameliorated the tissue damage scores. The results showed that Dxp reduced ovarian I/R injury.en_US
dc.identifier.doi10.1007/s00404-017-4287-y
dc.identifier.endpage784en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue3en_US
dc.identifier.pmid28105490en_US
dc.identifier.scopus2-s2.0-85009844368en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage777en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-017-4287-y
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11540
dc.identifier.volume295en_US
dc.identifier.wosWOS:000395012300027en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOvarian torsionen_US
dc.subjectIschaemia/reperfusionen_US
dc.subjectOxidative stressen_US
dc.subjectDexpanthenolen_US
dc.titleThe effect of dexpanthenol on experimentally induced ovarian ischaemia/reperfusion injury: a biochemical and histopathological evaluationen_US
dc.typeArticleen_US

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