Detection of borderline dosage of malathion intoxication in a rat's brain

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dc.authoridEvliyaoglu, Osman/0000-0002-5780-9068
dc.authoridYUCEL, YAVUZ/0000-0003-4205-3138
dc.contributor.authorVarol, S.
dc.contributor.authorBasarslan, S. K.
dc.contributor.authorFirat, U.
dc.contributor.authorAlp, H.
dc.contributor.authorUzar, E.
dc.contributor.authorArikanoglu, A.
dc.contributor.authorEvliyaoglu, O.
dc.date.accessioned2024-09-18T20:29:41Z
dc.date.available2024-09-18T20:29:41Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: Humans and other animals are liable to expose to low doses of malathion (MAL). However, experimental studies on its toxic threshold dose and toxic low-dose effects have not been conducted. The aims of this study were to detect the initiation of the toxic effects of sub-acute low doses (2.5, 5, and 10 mg/kg) of MAL by immunohistochemical and biochemical parameters in rat brain. MATERIALS AND METHODS: Twenty-eight rats were randomly assigned into four groups (n=7) including control and three different amounts of MAL-exposed groups (2.5, 5, and 10 mg/kg). RESULTS: On immunohistochemical examination, the number of caspase-3-positive cells in all MAL-exposed groups was significantly higher than in the control group. Consistent with this, the total antioxidant capacity, total oxidant status, and the levels of superoxide dismutase, malondialdehyde, and paraoxanase activity were significantly different in the 5 and 10 mg/kg MAL-exposed groups compared with the control group. Additionally, the total oxidant status and malondialdehyde levels were significantly higher in the 5 and 10 mg/kg MAL-exposed groups compared with those in the 2.5 mg/kg MAL-exposed group. CONCLUSIONS: Our results indicate that over 5 mg/kg MAL exposure may result in dose-dependent oxidative stress, increased caspase-3 activity, and launching to the toxic effects in rat brain.en_US
dc.identifier.endpage2323en_US
dc.identifier.issn1128-3602
dc.identifier.issue12en_US
dc.identifier.pmid26166662en_US
dc.identifier.scopus2-s2.0-84942280034en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2318en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11013
dc.identifier.volume19en_US
dc.identifier.wosWOS:000357991900031en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMalathionen_US
dc.subjectIts toxic dosageen_US
dc.subjectOxidative stressen_US
dc.subjectRat brainen_US
dc.titleDetection of borderline dosage of malathion intoxication in a rat's brainen_US
dc.typeArticleen_US

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