Vascular effect of levonorgestrel intrauterine system on heavy menstrual bleeding: is it associated with hemodynamic changes in uterine, radial, and spiral arteries?

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dc.authoridSEZGIN, BURAK/0000-0003-2938-5816
dc.authoridBayik, Rahime Nida/0000-0003-1805-2178
dc.contributor.authorSahin, Hanifi
dc.contributor.authorGungoren, Arif
dc.contributor.authorSezgin, Burak
dc.contributor.authorUn, Burak
dc.contributor.authorSahin, Eda Adeviye
dc.contributor.authorDolapcioglu, Kenan
dc.contributor.authorBayik, Rahime Nida
dc.date.accessioned2024-09-18T20:29:33Z
dc.date.available2024-09-18T20:29:33Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the clinical and blood flow changes associated with the use of a levonorgestrel-releasing intrauterine device (LNG-IUD) in patients with idiopathic heavy menstrual bleeding (HMB). LNG-IUD was inserted into a total of 91 patients (39.5 +/- 5.4 years) who were diagnosed with HMB. Uterine volume, ovarian volume, uterine, radial and spiral artery blood flow, Pictorial Blood Loss Assessment Chart (PBAC) scores, and other clinical and laboratory parameters were evaluated before and 12 months after insertion of LNG-IUD. Compared to pre-insertion values, LNG-IUD dramatically improved haemoglobin, PBAC scores, and endometrial thickness. Mean resistance indices of radial and spiral arteries significantly increased 12 months after insertion. Our study results suggest that a significant increase in the resistance indices of the intra-myometrial arteries in LNG-IUD users one year after insertion may be due to its local progestational effects, indicating a possible mechanism of LNG-IUD in reducing menstrual blood flow.Impact Statements What is already known on this subject?The mechanisms of action of LNG-IUD on heavy menstrual bleeding include atrophy, decidualization and vascular changes of in the endometrium, resulting endometrial suppression. However, the exact mechanism to stop bleeding is not clear. What do the results of this study add?The present study suggests that one of the effects of the LNG-IUD on heavy menstrual bleeding is its ability to increase the resistance indexes of the intra-myometrial arteries. What are the implications of these findings for clinical practice and/or further research?These results will foster further studies on the effects of LNG-IUD on intra-myometrial arteries and will further assure clinicians on the vascular effect of LNG-IUD during management of heavy menstrual bleeding which includes hysterectomy as a final step.en_US
dc.identifier.doi10.1080/01443615.2019.1671816
dc.identifier.endpage93en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue1en_US
dc.identifier.pmid32573299en_US
dc.identifier.scopus2-s2.0-85087381887en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2019.1671816
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10936
dc.identifier.volume41en_US
dc.identifier.wosWOS:000547310500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectlevonorgestrel-releasing intrauterine deviceen_US
dc.subjectheavy menstrual bleedingen_US
dc.subjectresistance indexen_US
dc.subjectpulsatility indexen_US
dc.titleVascular effect of levonorgestrel intrauterine system on heavy menstrual bleeding: is it associated with hemodynamic changes in uterine, radial, and spiral arteries?en_US
dc.typeArticleen_US

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