PROLIDASE ACTIVITY AND OXIDATIVE STRESS IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER

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dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorKokacya, Mehmet Hanifi
dc.contributor.authorBahceci, Bulent
dc.contributor.authorBahceci, Ilkay
dc.contributor.authorDilek, Aziz Ramazan
dc.contributor.authorDokuyucu, Recep
dc.date.accessioned2024-09-18T20:55:28Z
dc.date.available2024-09-18T20:55:28Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: The aim of the current study was to determine whether the serum prolidase levels are associated with the etiopathogenesis of depression. Subjects and methods: This study included 29 patients with major depressive disorder (MDD), who were consecutively recruited from the psychiatric outpatient clinic, and 30 healthy individuals recruited from the general community. Each patient underwent a detailed diagnostic evaluation by two psychiatrists using the Structured Clinical Interview for DSM-IV (SCID-I). Serum prolidase activity and oxidative parameters were measured in the patient and control groups. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale. Results: Serum prolidase level was significantly higher in patients with MDD compared to healthy subjects (p<0.001). Total Oxidant Status (TOS) levels and Oxidative Stress Index (OSI) were also significantly higher in patients with MDD (p<0.001), whereas no significant difference was observed between the groups in the TAS levels (p=0.297). Serum prolidase level did not show any correlation with markers of oxidative stress in patients with MDD. Conclusion: Increased serum prolidase levels in patients with MDD may be interpreted as the interaction of prolidase activity, glutamate transmission and oxidative stress. It is suggested that prolidase activity is involved in the etiopathogenesis of depressive disorder.en_US
dc.identifier.endpage318en_US
dc.identifier.issn0353-5053
dc.identifier.issue4en_US
dc.identifier.pmid25377365en_US
dc.identifier.startpage314en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11848
dc.identifier.volume26en_US
dc.identifier.wosWOS:000346149600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedicinska Nakladaen_US
dc.relation.ispartofPsychiatria Danubinaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectprolidase activityen_US
dc.subjectoxidative stressen_US
dc.subjectmajor depressive disorderen_US
dc.subjectMDDen_US
dc.subjectprolineen_US
dc.titlePROLIDASE ACTIVITY AND OXIDATIVE STRESS IN PATIENTS WITH MAJOR DEPRESSIVE DISORDERen_US
dc.typeArticleen_US

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