The investigation of heat shock protein (HSP 27), malondialdehyde (MDA), nitric oxide (NO) and interleukin (IL-6, IL-10) levels in cattle with anaplasmosis
[ N/A ]
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
KAFKAS UNIVERSITY
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Blood parasitic diseases such as tropical theileriosis in cattles are observed in Turkey. On the other hand, babesiosis and anaplasmaosis are other primer tick-borne diseases. Anaplasmosis is generalised in all over the region of Turkey. In the present study, we aimed to reveal the alterations of immune system and oxidative stress in cattles with anaplasmosis by analysing heat shock protein (HSP 27), malondialdehyde (MDA), nitric oxide (NO), interleukin-6 (IL-6) and interleukin-10 (IL-10) levels. The research has been performed on 15 healthy and 15 cattles with anaplasmosis, aged 1-3 years old. The plasma levels of malondialdehyde and nitric oxide were determined by spectrophotometric methods while the concentrations of heat shock protein and interleukin (IL-6 and IL-10) were detected by using commercial ELISA kits. The levels of plasma MDA (P<0.001), NO (P<0.001), HSP 27 (P<0.01) and serum IL-6 levels were determined significantly higher in cattles with anaplasmosis than the control group. The levels of serum IL-10 was not showed significant differences between the control and the patient group. The increases in the levels of malondialdehyde, nitric oxide, HSP 27 and interleukin-6 of the cattles with anaplasmosis may indicate the stimulation of host immune system and the existence of oxidative stress. In conclusion, determination of the levels of malondialdehyde, nitric oxide, HSP 27 and interleukin-6 might be a indicator for diagnosis of cattle anaplasmosis.
Açıklama
Anahtar Kelimeler
Anaplasmosis, Cattle, Interleukin, Malondialdehyde Heat shock protein, Nitric oxide
Kaynak
Kafkas Universitesi Veteriner Fakultesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
15
Sayı
4
