Does MCT1-T1470A Polymorphism Modify Lactate Kinetics and Training Status?

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dc.contributor.authorTurgay, Faruk
dc.contributor.authorBilgin, Zafer
dc.contributor.authorYigitturk, Oya
dc.contributor.authorDurmaz, Burak
dc.contributor.authorAsikovali, Semih
dc.contributor.authorKoksala, Ahmet
dc.date.accessioned2024-09-18T20:29:46Z
dc.date.available2024-09-18T20:29:46Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractStudy Objectives: The (MCT1-T1470A) polymorphism related to monocarboxylate transporters 1 (MCTs) which transport lactate (LA) may affect LA kinetics and training status, which is unclear. Methods: Participants in the athletic group (AG; 42 anaerobic athletes; 21.8 +/- 2.7 years) and the control group (CG; 39 sedentary men; 23.0 +/- 3.3 years) performed the Yoyo recovery level 1 test. LA elimination speeds were calculated by dividing the difference between LA5, LA15, and LA30 values of passive recovery corresponding to the 5th, 15th, and 30th minutes following the Yoyo test by the elapsed time. MCT1 polymorphism was determined from genomic DNA samples by next-generation sequencing. Results:The LA5, LA15, and LA30 values of the control group were significantly higher than those of the athlete group (p=0.053, p=0.042, and p=0.028, respectively), but not for LA elimination speeds. There was no significant difference for these parameters between genotype groups. Although the VO2max of the AA control group was significantly greater than that of the T carrier ( Tc) control group, there was no significant difference for VO2max between the athletic genotype groups (AA and Tc). Conclusions: MCT1-T1470A polymorphism did not have a significant effect on LA kinetics in athletes. However, the AA group was negatively affected for VO2max compared to the Tc group. This may be due to extreme sensitivity of the AA group to the training caused by this polymorphism. Further studies are needed to shed light on this entity.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination department [18-SPR-004]en_US
dc.description.sponsorshipThis research was funded by a grant from Ege University Scientific Research Projects Coordination department (18-SPR-004).en_US
dc.identifier.doi10.23751/pn.v23iS2.11997
dc.identifier.issn1129-8723
dc.identifier.urihttps://doi.org/10.23751/pn.v23iS2.11997
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11050
dc.identifier.volume23en_US
dc.identifier.wosWOS:000697163200013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherMattioli 1885en_US
dc.relation.ispartofProgress in Nutritionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMCT1-T1470Aen_US
dc.subjectPolymorphismen_US
dc.subjectLactate transportersen_US
dc.subjectAnaerobic exerciseen_US
dc.subjectLactate eliminationen_US
dc.titleDoes MCT1-T1470A Polymorphism Modify Lactate Kinetics and Training Status?en_US
dc.typeArticleen_US

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