Behavioral and Cognitive Consequences of Obesity in Parents and Offspring in Female and Male Rats: Implications of Neuroinflammation and Neuromodulation

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dc.authoridDemir, Enver/0000-0002-2620-6192
dc.authoridCimen Acikgul, Funda/0000-0002-8904-1444
dc.contributor.authorDemir, Enver Ahmet
dc.contributor.authorGulbol-Duran, Gulay
dc.contributor.authorUrhan-Kucuk, Meral
dc.contributor.authorDogan, Hatice
dc.contributor.authorTutuk, Okan
dc.contributor.authorCimen, Funda
dc.contributor.authorBayirli, Mucella
dc.date.accessioned2024-09-18T20:52:50Z
dc.date.available2024-09-18T20:52:50Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObesity is a rapidly growing public health concern that can create a family-wise burden. This study was aimed to investigate behavioral, cognitive, neuroinflammatory, and neuromodulatory consequences of the diet and parental obesity. Female and male Wistar albino rats were fed on either an obesogenic or standard diet for 12 weeks, beginning with weaning. Thereafter, the animals were matched and allowed to mate. Pups born to obese or normal parents received either the diet or standard chow to the same age. The obesogenic diet and/or parental obesity increased the locomotor activity in both females and males. The diet exhibited anxiolytic-like and antidepressant-like properties, and impaired short-term object memory as well as spatial memory. Interestingly, the obesogenic diet resulted in neuroinflammation only in naive animals, but not in the ones with parental obesity. BDNF, SIRT1, and p53 expressions were decreased, whereas RelN expression was increased in the brain with the diet, regardless of parental obesity. Multi-factor analyses demonstrated that the obesogenic diet is the prominent influencer of cognitive, neuroinflammatory, and neuromodulatory results while parental obesity has an effect on spatial memory, neuroinflammation, and hippocampal RelN and p53 expressions. Here, we provided supporting evidence for detrimental cognitive and neuroinflammatory consequences of early life consumption of the obesogenic diet which accompanies alterations in neuromodulatory factors. Surprisingly, the diet was found beneficial against anxiety-like and depression-like behaviors, and additionally, parental obesity was demonstrated to impair some aspects of cognitive performance which appears unrelated to neuroinflammation.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-3501/#118S404]en_US
dc.description.sponsorshipThis study has been supported by the Scientific and Technological Research Council of Turkey (TUBITAK-3501/#118S404).en_US
dc.identifier.doi10.1007/s12035-022-02831-5
dc.identifier.endpage3968en_US
dc.identifier.issn0893-7648
dc.identifier.issn1559-1182
dc.identifier.issue6en_US
dc.identifier.pmid35438432en_US
dc.identifier.scopus2-s2.0-85128342766en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3947en_US
dc.identifier.urihttps://doi.org/10.1007/s12035-022-02831-5
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11440
dc.identifier.volume59en_US
dc.identifier.wosWOS:000786481200002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Neurobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOffspringen_US
dc.subjectObesityen_US
dc.subjectBehavioren_US
dc.subjectCognitionen_US
dc.subjectNeuroinflammationen_US
dc.subjectNeuromodulationen_US
dc.titleBehavioral and Cognitive Consequences of Obesity in Parents and Offspring in Female and Male Rats: Implications of Neuroinflammation and Neuromodulationen_US
dc.typeArticleen_US

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