Is Low-free Triiodothyronine (fT3) Associated with Increased Morbidity in Patients Admitted to Coronary Care Units?

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dc.contributor.authorAkkus, Oguz
dc.contributor.authorSen, Fatih
dc.contributor.authorYasdibas, Ramazan
dc.contributor.authorOtegen, Alper Tunga
dc.contributor.authorHuzmeli, Irem
dc.contributor.authorAkkus, Gamze
dc.date.accessioned2024-09-18T19:50:19Z
dc.date.available2024-09-18T19:50:19Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: The effects of thyroid hormone on patients hospitalized in coronary intensive care units are still controversial. Objective: We retrospectively examined thyroid hormone levels and their impact on cardiovascular morbidity in patients admitted to coronary intensive care units. Methods: A total of 208 (Female/Male; 46.6%/53.4%) patients without any history of thyroid disease were enrolled and screened. Patients with specific heart disease and existing thyroid hormone parameters were included in the study. Low triiodothyronine syndrome is characterized by reduced serum total or free T3 (fT3) concentrations in normal free T4 (fT4) and TSH levels. Results: The common diagnosis of the patients in the coronary care unit is acute coronary syndrome (n=59, 28.2%) and heart failure (n=46, 23.3%). Patients were divided into two groups according to left ventricular ejection fraction percentages (LVEF <= 39% vs LVEF >= 40%). Plasma fT3 levels were significantly correlated with low LVEF (<= 39%) (p =0.002). fT3 (r=-0.183, p =0.013) and hospitalization etiology (r=-0.161, p =0.023) were also the most critical parameters affecting the length of hospitalization. Conclusion: Low fT3 was associated with reduced ejection fraction and prolonged hospitalization, which may lead to potential morbidities in HF patients which may be useful in risk stratification and treatment strategies.en_US
dc.description.sponsorshipDeclared none.en_US
dc.identifier.doi10.2174/0118715303287732240201122412
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.pmid38706313en_US
dc.identifier.urihttps://doi.org/10.2174/0118715303287732240201122412
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7355
dc.identifier.wosWOS:001299804800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targetsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute coronary syndromeen_US
dc.subjectcoronary care uniten_US
dc.subjecteuthyroid sick syndromeen_US
dc.subjectheart failureen_US
dc.subjectpatientsen_US
dc.subjectventricular ejection fraction percentagesen_US
dc.titleIs Low-free Triiodothyronine (fT3) Associated with Increased Morbidity in Patients Admitted to Coronary Care Units?en_US
dc.typeArticleen_US

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