THE PROTECT WE EFFECTS OF LYCOPENE ON THE LOSS OF BODY WEIGHT AND HISTOPATHOLOGICAL LESIONS IN LIVER, KIDNEY, HEART, AND BRAIN TISSUE OF RATS EXPOSED TO SUBCHRONICALLY DIFFERENTIAL DOSES OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN

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dc.authoridSERVI, Kadir/0000-0001-5610-9505
dc.authoridCeribasi, Ali Osman/0000-0002-6096-4042
dc.contributor.authorSakin, Fatih
dc.contributor.authorCeribasi, Ali Osman
dc.contributor.authorServi, Kadir
dc.contributor.authorLacramioara, Popa
dc.date.accessioned2024-09-18T20:15:14Z
dc.date.available2024-09-18T20:15:14Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the possible protective role of lycopene (LYC) on body weight changes, and histopathological lesions on liver, kidney, heart, and brain tissue in male rats exposed to subchronically differential doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic xenobiotic. Forty-eight rats were divided into six groups. The first group received 0.5 mL corn oil as control; the second group was treated with 10 mg/kg bw/day LYC. Groups 3 and 4 were treated with 50 and 500 ng/kg bw/day of TCDD, respectively. Groups 5 and 6 were subjected to 50 and 500 ng/kg bw/day of TCDD along with 10 mg/kg bw/day of LYC, simultaneously. The period of the experiment was 13 weeks. In TCDD-treated groups, a dose-related depression of mean body weight was observed when compared to control. Simultaneously LYC administration reduced the loss of body weight and partially or totally recovered the formed histopathological lesions in liver, kidney, and heart tissue of rats exposed to TCDD. As a result, it is suggested that LYC has a protective effect against the loss of body weight and toxicity caused by TCDD.en_US
dc.description.sponsorshipResearch Foundation of Firat University [1442]; Scientific and Technological Research Council of Turkey (TUBITAK) [106O828]en_US
dc.description.sponsorshipThe authors acknowledge financial support from the Research Foundation of Firat University (Project number: 1442) and the Scientific and Technological Research Council of Turkey (TUBITAK) (Project number: 106O828).en_US
dc.identifier.endpage870en_US
dc.identifier.issn0014-8237
dc.identifier.issue6en_US
dc.identifier.startpage860en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9524
dc.identifier.volume59en_US
dc.identifier.wosWOS:000298826500015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSoc Stinte Farmaceutice Romaniaen_US
dc.relation.ispartofFarmaciaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectdioxinen_US
dc.subjecttoxicityen_US
dc.subjecthistopathologyen_US
dc.subjectlycopeneen_US
dc.titleTHE PROTECT WE EFFECTS OF LYCOPENE ON THE LOSS OF BODY WEIGHT AND HISTOPATHOLOGICAL LESIONS IN LIVER, KIDNEY, HEART, AND BRAIN TISSUE OF RATS EXPOSED TO SUBCHRONICALLY DIFFERENTIAL DOSES OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXINen_US
dc.typeArticleen_US

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