THE EFFECTS OF ERDOSTEINE ON COAGULATION IN RATS
[ N/A ]
Tarih
2014
Yazarlar
Motor, Sedat
Alp, Harun
Yuksel, Rana
Erden, Ersin Sukru
Oktar, Suleyman
Celik, Salih
Cayirci, Gokhan
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Carbone Editore
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and objectives: Erdosteine, a thiol derivative in the same group as N-acetyl cysteine, belongs to a class of medicines called expectorants. Aim: It was aimed to determine effects of erdosteine (ERD) on coagulation. Material and methods: A total of 23 female rats were divided into three groups as control (C) (n=7), ERD-10 (n=7), ERD-50 (n=9). Rats in C group were given dilution of 0.3 ml sodium bicarbonate [NaHCO3]; rats in ERD-10 group were given 10 mg/kg ERD; and rats in ERD-50 group were given 50 mg/kg ERD. The drugs were given for ten days by oral gavage. Blood samples were drawn from the heart 24 hours after the last drug dose, and coagulation parameters were measured with automated analyzers. Results: While Factor VIII and AT-III levels decreased in both ERD-10 and ERD-50 group, Factor IX levels only decreased in ERD-50 group. Also, INR, PT and aPTT were prolonged in the ERD-50 group compared with the control and ERD-10 groups. There was no significant difference between groups for protein C and S. Conclusion: The results showed that erdosteine may increase bleeding tendencies in a dose-related manner. Therefore, we suggest that it should be noted when erdosteine is used together with anticoagulant medications. In addition, patients should be questioned regarding the use of erdosteine before dental or medical operations in order to prevent bleeding abnormalities.
Açıklama
Anahtar Kelimeler
erdosteine, coagulation, antithrombin III, factor VIII, factor IX, protrombin time (PT), activated partial tromboplastin time (aPTT), international normalized ratio (INR), protein C and S
Kaynak
Acta Medica Mediterranea
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
30
Sayı
4
