Effect of end-to-side repair of proximal nerve stumps of transected peripheral nerves on the development of neuroma (Experimental study)

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dc.authorscopusid13906591500
dc.authorscopusid6603868806
dc.authorscopusid6603096694
dc.authorscopusid56249743200
dc.authorscopusid23102174600
dc.authorscopusid6506772736
dc.authorscopusid7004376912
dc.contributor.authorAyan, Irfan
dc.contributor.authorBora, Arslan
dc.contributor.authorKarakaplan, Mustafa
dc.contributor.authorInan, Muharrem
dc.contributor.authorBostan, Bora
dc.contributor.authorGermen, Burak
dc.contributor.authorZorludemir, Suzan
dc.date.accessioned2024-09-19T15:47:09Z
dc.date.available2024-09-19T15:47:09Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Neuroma is a psychologically and physically disabling problematic condition without any current standard therapy. For that reason, we investigated whether end-to-side anastomosis of the proximal end of the transected nerve into the adjacent nerve will prevent the development of neuroma in different types of nerve injuries. Study design: In this study, hind legs of 18 Sprague - Dawley female rats were used. Six groups were formed. In group I, peroneal nerves were transected and its proximal end was attached end-to-side through the epineural window to the adjacent tibial nerve. In group II, contrary to group I, an epineural window was created in the tibial nerve and the same number of sutures were employed. In group III, tibial nerve was transected proximal to the end-to-side repair site, whereas in group IV, distal segment of the nerve was cut, and an end-to-end repair procedure was repeated. In group V, unlike group I, an approximately 1-cm segment was resected and removed distal (from tibial nerve) to the end-to-side repair site. In group VI, an epineural window was created in the tibial nerve and the same number of sutures were used, and also a 1-cm distal nerve segment was resected. The rats were followed for 2 months, and then all of the groups were evaluated histopathologically, and weights of the posterior muscle groups of hind legs were evaluated. Findings and Conclusions: No neuroma formation was observed in the proximal stumps of peroneal nerve segments in end-to-side repair sites in groups I, III, IV, and V, and proximal stumps of the tibial nerve in group V. In group VI, neuroma formation was observed in the proximal end of the tibial nerve. When weights of the posterior muscle groups of hind legs in groups I and II were comparatively assessed, statistically significant difference was not detected. In conclusion, based on histological data obtained for proximal nerve ends and segments distal to the end-to-side repair sites, we think that end to side neurorrhaphy of the proximal end of the damaged nerve to adjacent nerve will prevent the development of neuroma without injuring the intact nerve segment. © American Association for Hand Surgery 2007.en_US
dc.identifier.doi10.1007/s11552-007-9049-z
dc.identifier.endpage205en_US
dc.identifier.issn1558-9455
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-35848947051en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage199en_US
dc.identifier.urihttps://doi.org/10.1007/s11552-007-9049-z
dc.identifier.urihttps://hdl.handle.net/20.500.12483/15013
dc.identifier.volume2en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofHanden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEnd-to-sideen_US
dc.subjectNerveen_US
dc.subjectNeuromaen_US
dc.titleEffect of end-to-side repair of proximal nerve stumps of transected peripheral nerves on the development of neuroma (Experimental study)en_US
dc.typeArticleen_US

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