Mean Platelet Volume in Children with Familial Mediterranean Fever and the Relationship with Attack Status, Colchicine Treatment and Gene Mutation

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dc.contributor.authorUstun, Nilgun
dc.contributor.authorUlasli, Alper Murat
dc.contributor.authorCelik, Tanju
dc.contributor.authorYula, Erkan
dc.contributor.authorTurhanoglu, Ayse Dicle
dc.date.accessioned2024-09-18T20:20:01Z
dc.date.available2024-09-18T20:20:01Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIncreased mean platelet volume (MPV) is a manifestation of platelet functions and activation, and accepted as a prognostic biomarker in patients with cardiovascular disease. We aimed to investigate MPV levels in pediatric Famillial Mediterranean Fever (FMF) patients during the attack and attack-free periods, and the effect of colchicine treatment and presence of M694V mutation. Thirty-five pediatric patients with FMF and 38 age-sex-matched healty controls were enrolled retrospectively into the study. Of the patients 11 (31%) had an ongoing attack, and 24 (69%) were in attack-free period. 26 (74%) patients were receiving colchicine and 16 (45.7%) had M694V gene mutation. There was no significant difference in platelet (PLT) and MPV between patients and healthy controls (p=0.196 and p=0.167 respectively). Mean PLT and MPV values of the patients during attack and attack-free period were also not significantly different (p=0.355 and p=0.118 respectively). However, MPV levels during an FMF attack were non-significantly lower than healthy control group (p=0.08). PLT and MPV levels were higher in patients receiving colchicine but the differences were not significant (p=0.097 and p=0.446 respectively). Mean MPV value of the FMF patients with M694V mutation was not significantly different than controls (p=0.773). In conclusion, this study reveals that pediatric FMF patients have similar MPV levels with healthy individuals even in the presence of M694V mutation. MPV as an early atherosclerosis marker, is not significantly elevated in this patient cohort. Regular treatment with colchicine and younger age may have a role in non-impaired platelet activation in FMF patients.en_US
dc.identifier.doi10.15197/sabad.1.11.64
dc.identifier.endpage173en_US
dc.identifier.issn1304-3889
dc.identifier.issn1304-3897
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84908412418en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage169en_US
dc.identifier.urihttps://doi.org/10.15197/sabad.1.11.64
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10006
dc.identifier.volume11en_US
dc.identifier.wosWOS:000421937800007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherModestum Ltden_US
dc.relation.ispartofEuropean Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFamilial Mediterranean feveren_US
dc.subjectMEFV geneen_US
dc.subjectMean platelet volumeen_US
dc.subjectColchicineen_US
dc.titleMean Platelet Volume in Children with Familial Mediterranean Fever and the Relationship with Attack Status, Colchicine Treatment and Gene Mutationen_US
dc.typeArticleen_US

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