Surveilling brain damage using brain biomarkers in hypoglycemic neonatal calves with diarrhea

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dc.contributor.authorIder, Merve
dc.contributor.authorNaseri, Amir
dc.contributor.authorOk, Mahmut
dc.contributor.authorErturk, Alper
dc.contributor.authorDurgut, Murat Kaan
dc.contributor.authorIyigun, Suleyman Serhat
dc.date.accessioned2024-09-18T20:27:56Z
dc.date.available2024-09-18T20:27:56Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractHypoglycemia is a condition associated with neonatal diarrhea in calves, leading to increased mortality and neurological clinical signs. The aim of the present study was to determine the development of brain damage in hypoglycemic calves with neonatal diarrhea and the diagnostic and prognostic significance of these biomarkers. Ten healthy and 50 hypoglycemic calves with diarrhea were included in the study. Clinical examination, blood gases and complete blood count were performed at admission. Blood serum calcium-binding protein B (S100B), neuron-specific enolase (NSE), glial fibrillary acidic protein (GFAP), ubiquitin carboxyl-terminal hydrolysis isoenzyme-1 (UCHL-1), activitin A (ACT), adrenomodullin (AM) concentrations, and creatine kinase-BB (CK-BB) enzyme activity were measured using commercial bovine-specific ELISA kits to assess brain damage. Of the hypoglycemic calves enrolled in the study, 13 (26%) survived and 37 (74%) died. In addition, 32 (64%) of the calves had severe acidosis and 24 (48%) had sepsis. S100B, GFAP, UCHL-1, CK-BB (p < 0.001) and NSE (p < 0.05) concentrations were significantly higher in hypoglycemic calves compared to healthy calves, while ACT concentrations were lower. Blood glucose concentration was negatively correlated with serum S100B, GFAP, UCHL-1, and CK-BB enzyme activity and positively correlated with ACT in hypoglycemic calves (p < 0.01). Brain injury biomarkers were not predictive of mortality (p > 0.05). Morever, severe hypoglycemia, severe acidosis and sepsis variables were not found to have sufficient capacity to predict mortality when considered alone or together (p > 0.05). In conclusion, brain damage may develop as a consequence of hypoglycemia in calves. S100B, NSE, GFAP, UCHL-1, ACT, and CK-BB concentrations can be used to diagnose brain damage in hypoglycemic calves. However, the variables of severe hypoglycemia, severe acidosis, and sepsis together with the biomarkers of brain injury have a limited value in predicting the prognosis of neonatal calves with diarrhea.en_US
dc.description.sponsorshipThis research was supported by the Selcuk University Scientific Research Project Office with project number 22401100. [22401100]; Selcuk University Scientific Research Project Officeen_US
dc.description.sponsorshipThis research was supported by the Selcuk University Scientific Research Project Office with project number 22401100.en_US
dc.identifier.doi10.3389/fvets.2023.1240846
dc.identifier.issn2297-1769
dc.identifier.pmid38026658en_US
dc.identifier.scopus2-s2.0-85176773760en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fvets.2023.1240846
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10617
dc.identifier.volume10en_US
dc.identifier.wosWOS:001104488200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers in Veterinary Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthypoglycemiaen_US
dc.subjectneonatal calfen_US
dc.subjectbrain injuryen_US
dc.subjectbiomarkersen_US
dc.subjectprognosisen_US
dc.titleSurveilling brain damage using brain biomarkers in hypoglycemic neonatal calves with diarrheaen_US
dc.typeArticleen_US

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