Evaluation of the relationships between oxidative stress, inflammation, hormonal status and sperm parameters in rats: Canonical correlation analysis

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dc.authorscopusid57195584573
dc.authorscopusid57194024487
dc.contributor.authorKaya, Ufuk
dc.contributor.authorOlğaç, Kemal Tuna
dc.date.accessioned2024-09-19T15:45:24Z
dc.date.available2024-09-19T15:45:24Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractMany endocrine or non-endocrine factors are involved in sperm production. Although reproductive hormones are very important for the initiation and maintenance of spermatogenesis, other factors, such as inflammation and oxidative stress, affect spermatogenesis. The aim of this study is to evaluate the relationships between sperm parameters and hormones, oxidative stress, and inflammation status. We conducted this study on 40 rats. Sperm parameters (motility, abnormal sperm rate, and dead sperm rate), oxidative stress (malondialdehyde, glutathione, glutathione peroxidase, and catalase), inflammation (NF-??, TNF-?, IL-1?, IL-6, and IL-10), and hormone parameters (follicle-stimulating hormone, luteinizing hormone, testosterone, melatonin, and corticosterone) were determined. Relationships between mentioned parameters were investigated by canonical correlation analysis. Canonical correlation coefficients for these data sets (sperm-oxidative stress, sperm-inflammation, and sperm-hormone parameters) were found to be strongly significant (rc= 0.875, p<0.001; rc= 0.868, p<0.001; rc= 0.886, p<0.001, respectively). The rate of explanation of oxidative stress, inflammation parameters and hormones by sperm parameters was 61.80 %, 56.10 % and 63.90 %, respectively. Canonical correlation analysis results have revealed that dead sperm rate is mostly related to nuclear factor-kappa beta (NF-??), catalase, and corticosterone. CCA, which has taken into account the multiple relationships, has revealed that multidimensional evaluation of data sets can provide important and innovative information to researchers for the assessment of relationships between sperm, oxidative stress, inflammation, and hormone parameters. © 2024 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.jri.2024.104276
dc.identifier.issn0165-0378
dc.identifier.pmid38896933en_US
dc.identifier.scopus2-s2.0-85196158327en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jri.2024.104276
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14660
dc.identifier.volume164en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofJournal of Reproductive Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanonical correlationen_US
dc.subjectHormonesen_US
dc.subjectInflammationen_US
dc.subjectOxidative stressen_US
dc.subjectRat semenen_US
dc.titleEvaluation of the relationships between oxidative stress, inflammation, hormonal status and sperm parameters in rats: Canonical correlation analysisen_US
dc.typeArticleen_US

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