Is there a relationship between keratoconus and ocular Demodex mites?

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dc.authorscopusid56150894400
dc.authorscopusid55584788000
dc.authorscopusid57216709839
dc.authorscopusid56699954200
dc.contributor.authorKurtul, Bengi Ece
dc.contributor.authorKaya, Ozlem Makbule
dc.contributor.authorKakac, Ahmet
dc.contributor.authorCetinkaya, Yasemin Fatma
dc.date.accessioned2024-09-19T15:47:00Z
dc.date.available2024-09-19T15:47:00Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBACKGROUND: The background of this study was to evaluate the relationship between keratoconus (KC) occurrence and ocular Demodex infestation together with the effects of Demodex on the ocular surface. METHODS: Thirty-eight eyes of 20 KC patients (KC group) and 40 eyes of 20 age- and sex-matched healthy subjects (control group) were included in this cross-sectional study. Demodex species (folliculorum/brevis), clinical symptoms such as eye rubbing, Ocular Surface Disease Index (OSDI), corneal topography findings, tear break-up time (TBUT), and Schirmer test scores were evaluated. KC eyes were also divided into two subgroups according to KC severity and presence of Demodex. Demodex was detected using conventional light microscopy. RESULTS: The mean age was 25.90 ± 7.01 years in the KC group, and 26.52 ± 8.94 years in the control group (P = 0.731). While unexpectedly no Demodex were detected in the control group, Demodex were detected in the KC group, including 8 eyes (21.1%) with Demodex folliculorum, and 10 eyes with D. folliculorum + Demodex brevis (26.3%) (P < 0.001). As the KC severity worsened, the percentage of eyes with Demodex mites increased (43.8% in the mild/moderate subgroup and 66.7% in the severe subgroup, P < 0.001). The number of rubbing eyes and OSDI scores were significantly higher, and TBUT levels were significantly lower in the KC Demodex + and Demodex - subgroups than the control group (P < 0.001 for all), but there is no significant difference between the KC Demodex + and Demodex - subgroups regarding ocular surface parameters (P = 1.0). CONCLUSIONS: Although the number of patients is relatively small and there is no follow-up data after Demodex treatment, KC and ocular Demodex infestation seem to be associated. Demodex-related inflammation and associated eye rubbing may contribute to KC progression. © 2023 Wolters Kluwer Medknow Publications. All rights reserved.en_US
dc.identifier.doi10.4103/ojo.ojo_270_22
dc.identifier.endpage292en_US
dc.identifier.issn0974-620X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85165937919en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage287en_US
dc.identifier.urihttps://doi.org/10.4103/ojo.ojo_270_22
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14908
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofOman Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDemodex brevisen_US
dc.subjectDemodex folliculorumen_US
dc.subjectkeratoconusen_US
dc.subjectocular surfaceen_US
dc.subjectseverityen_US
dc.titleIs there a relationship between keratoconus and ocular Demodex mites?en_US
dc.typeArticleen_US

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