SYNERGISTIC ACTIVITIES OF Hypericum perforatum L. AND GLABRIDIN AGAINST DRUG RESISTANT H. pylori ISOLATES

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dc.authoridKaya, Durmus Alpaslan/0000-0003-3544-9214
dc.contributor.authorDuran, Nizami
dc.contributor.authorKaya, Durmus Alpaslan
dc.date.accessioned2024-09-18T20:27:55Z
dc.date.available2024-09-18T20:27:55Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description7th International Conference on Advanced Materials and Systems -- OCT 18-20, 2018 -- Bucharest, ROMANIAen_US
dc.description.abstractGlabridin and Hypericum perforatum L. have many pharmacological activities such as antimicrobial activity, antiproliferative, cytotoxic, anticancerogenic, antiproliferative and antioxidant effect. The aim of this study was to determine the components and to investigate the antimicrobial activity of Hypericum perforatum L. and glabridin against drug resistant H. pylon isolates. The main essential oil components of Hypericum perforatum L. determined by GC-MS were caryophyllene (19,13 %), germacrene-D (13,22 %), alpha-Pinene (12,59 %) and beta-helmiscapene (8,99 %). We also aim to determine the synergistic activity of these two natural products against the drug-resistant H. pylori strains. MIC values of Hypericum perforatum L. essential oils and glabridin against drug resistant H. pylori isolates were carried out by modifying the method described previously. In the experiments in which 1:1 ratio of Hypericum perforatum L. essential oils and glabridin was used, the MIC values (mu g/mL) were as follows: 8 For standard strain; 4 for drug sensitive strain; 8 for metronidazole resistant strain; and 16 for clarithromycin resistant strains. In conclusion, it was found that Hypericum perforatum L. essential oils and glabridin had significant antimicrobial activity against HP strains in our study.en_US
dc.description.sponsorshipMinist Res & Innovat,Natl Res & Dev Inst Textile & Leather, Div Leather & Footwear Res Insten_US
dc.identifier.doi10.24264/icams-2018.I.12
dc.identifier.endpage92en_US
dc.identifier.scopus2-s2.0-85111839641en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage87en_US
dc.identifier.urihttps://doi.org/10.24264/icams-2018.I.12
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10600
dc.identifier.wosWOS:000464905000012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIncdtp-Icpien_US
dc.relation.ispartofProceedings of The 7th International Conference on Advanced Materials and Systemsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypericum perforatumen_US
dc.subjectglabridinen_US
dc.subjectH. pylorien_US
dc.subjectdrugen_US
dc.subjectresistanten_US
dc.subjectstrainen_US
dc.titleSYNERGISTIC ACTIVITIES OF Hypericum perforatum L. AND GLABRIDIN AGAINST DRUG RESISTANT H. pylori ISOLATESen_US
dc.typeConference Objecten_US

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