The effect of obesity on inflammatory markers in patients with PCOS: a BMI-matched case-control study

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dc.contributor.authorKurt, Raziye Keskin
dc.contributor.authorOkyay, Ayse Guler
dc.contributor.authorHakverdi, Ali Ulvi
dc.contributor.authorGungoren, Arif
dc.contributor.authorDolapcioglu, Kenan Serdar
dc.contributor.authorKarateke, Atilla
dc.contributor.authorDogan, Mustafa Ozcil
dc.date.accessioned2024-09-18T20:54:21Z
dc.date.available2024-09-18T20:54:21Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPrevious studies have shown increased inflammatory activity in patients with polycystic ovary syndrome (PCOS); however, it remains uncertain whether this increased inflammatory activity is a consequence of the disorder itself or of the accompanying obesity. We therefore aimed to test the inflammatory marker levels in obese and lean patients with PCOS by using two separate control groups with matching body mass index (BMI). A total of 120 women in reproductive age with (n = 62) and without (n = 60) PCOS were recruited for the study. Patients with PCOS were divided into two groups as obese (n = 32) and lean (n = 30) PCOS groups according to BMI. Two BMI-matched control groups were created. Furthermore, high sensitive CRP protein (hsCRP), neutrophils, lymphocytes, white blood cell count (WBC) and neutrophil to lymphocyte ratio (NLR) were evaluated with complete blood count. The hsCRP (5.5 +/- A 0.8 vs. 3.1 +/- A 0.7, p < 0.001), neutrophil count (3.8 +/- A 0.4 vs. 2.9 +/- A 0.7, p < 0.001), leukocyte count (7.2 +/- A 1.8 vs. 5.6 +/- A 1.6, p < 0.001), and NLR (2.6 +/- A 1.4 vs. 1.5 +/- A 0.4, p < 0.001) were higher in patients with PCOS compared to the control group while lymphocyte count was lower (1.71 +/- A 0.65 vs. 1.98 +/- A 0.39, p = 0.008). Similarly, both obese and lean patients with PCOS had higher levels of hsCRP, neutrophils, leukocytes and NLR ratios compared to BMI-matched controls. The correlation analysis revealed a moderate correlation between NLR and hsCRP (r 0.459, p < 0.001), and between HOMA-IR (r 0.476 p < 0.001) and BMI (r 0.310, p 0.001). Our study results demonstrated that both lean and obese patients with PCOS have increased inflammatory markers compared to BMI-matched control groups indicating that the inflammation seen in PCOS might be related with the presence of the disorder rather than with obesity.en_US
dc.identifier.doi10.1007/s00404-014-3199-3
dc.identifier.endpage319en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue2en_US
dc.identifier.pmid24643802en_US
dc.identifier.scopus2-s2.0-84904565346en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage315en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-014-3199-3
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11762
dc.identifier.volume290en_US
dc.identifier.wosWOS:000339727400020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectNeutrophil lymphocyte ratioen_US
dc.subjectInflammationen_US
dc.subjectObesityen_US
dc.titleThe effect of obesity on inflammatory markers in patients with PCOS: a BMI-matched case-control studyen_US
dc.typeArticleen_US

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