Protective effect of Diospyros kaki L. leaves extract against oxidative damage and inflammation in the testicular ischemia-reperfusion model in rats

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dc.contributor.authorYurtal, Ziya
dc.contributor.authorKulualp, Kadri
dc.contributor.authorOezkan, Hueseyin
dc.contributor.authorKutlu, Tuncer
dc.contributor.authorAlakus, Halil
dc.contributor.authorAslan, Abdullah
dc.contributor.authorAltug, Muhammed E.
dc.date.accessioned2024-09-18T20:08:19Z
dc.date.available2024-09-18T20:08:19Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractThe Oriental persimmon, Diospyros kaki L., native of China, with its bioactive compounds from leaves, flavonoids and polyphenols in particular, possess antibacterial, antiallergic, anti-inflammatory, neuroprotective and antihypertensive properties. Though, the anti-inflammatory and antioxidative effects of the D. kaki leaves have beneficial effects in I/R injury in the brain, the same has not been investigated in testicular I/R injury until now. Hence, in the present study, we investigated its leaf extract against oxidative damage and inflammation in the testicular ischemia-reperfusion model. Thirty-two male rats were randomly and equally divided into four groups. While saline (SF) was given to the control and ischemia/reperfusion (I/R) groups for 5 days, Diospyros kaki (DK) and I/R+DK were given 200 mg/kg of DK leaf extract. Afterwards, left orchiectomy was performed in control and DK, and testicular torsion was performed in I/R and I/R+DK for 2 hours. All rats were sacrificed 24 hours after procedures and samples were collected. Compared to the control, I/R had high MDA levels, low GSH and GSH-Px levels; compared to the I/R, MDA levels of the I/R+DK were lower, and the GSH and GSH-Px levels were higher. In I/R, the presence of congestion and hemorrhage were determined and the deterioration in seminiferous tubule structure and spermatogenesis were less in the I/R+DK. TNF-alpha, COX-2, BCL-2, and BAX genes expressions were significantly lower in the I/R+DK group. TNF-alpha and COX-2 proteins were higher in I/R and I/R+DK groups, while NRF2 was higher in I/R+DK. These results show that DK leaves extract has crucial protective effect against oxidative damage and inflammation in the I/R model of rats.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Hatay Mustafa Kemal University [21]en_US
dc.description.sponsorshipFunding This study was supported by the Scientific Research Projects Coordination Unit of Hatay Mustafa Kemal University (Project No. 21.GAP.053) .en_US
dc.identifier.doi10.56042/ijeb.v61i09.3638
dc.identifier.endpage880en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.issue11en_US
dc.identifier.startpage871en_US
dc.identifier.urihttps://doi.org/10.56042/ijeb.v61i09.3638
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8772
dc.identifier.volume61en_US
dc.identifier.wosWOS:001115798500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal of Experimental Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChinese persimmonen_US
dc.subjectJapanese persimmonen_US
dc.subjectOriental persimmonen_US
dc.subjectReactive oxygen species (ROS)en_US
dc.subjectTesticularen_US
dc.subjecttorsionen_US
dc.titleProtective effect of Diospyros kaki L. leaves extract against oxidative damage and inflammation in the testicular ischemia-reperfusion model in ratsen_US
dc.typeArticleen_US

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