QTc Intervals in Drug Poisoning Patients with Tricyclic Antidepressants and Selective Serotonin Reuptake Inhibitors

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dc.authoridAvci, Akkan/0000-0002-4627-0909
dc.contributor.authorAcikalin, Ayca
dc.contributor.authorSatar, Salim
dc.contributor.authorAvci, Akkan
dc.contributor.authorTopal, Metin
dc.contributor.authorKuvandik, Gueven
dc.contributor.authorSebe, Ahmet
dc.date.accessioned2024-09-18T20:55:35Z
dc.date.available2024-09-18T20:55:35Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCommonly used agents of drug poisoning among patients who come to the emergency services are tricyclic antidepressants (TCAs). These drugs may cause defect in cardiac conduction due to the slowdown in the cardiac depolarization and expansions in the QT interval. Selective serotonin reuptake inhibitors (SSRIs) are less expansion of the QT period and lower cardio toxic side effects. The aim of this study was to investigate QTc intervals and prognosis of the patients who come to the emergency service due to TCA and SSRI group antidepressant drug poisoning. In a study of 96 patients, 75 of whom were diagnosed to be poisoned by TCAs (TCA group) and 21 by SSRIs (SSRI group) were examined. Electrocardiographic alterations and QTc intervals all of patients were evaluated. QTc intervals of patients in TCA group were deter-mined to be slightly more than those in SSRI group and it was not statistically significant. In the SSRI group, only one patient had QTc period more than 500 milliseconds (520 milliseconds); however, TCA overdose showed 9 (12%) patients with QTc interval over 500 milliseconds, and QTc values of 2 patients were over 600 milliseconds. In our study, it was determined that SSRI group drugs caused similar expansion of the QTc period as TCA drugs but they did not reach high values like TCA drugs, and their OR intervals stayed in more innocent levels.en_US
dc.identifier.doi10.1097/MJT.0b013e318197eec6
dc.identifier.endpage33en_US
dc.identifier.issn1075-2765
dc.identifier.issue1en_US
dc.identifier.pmid19417591en_US
dc.identifier.scopus2-s2.0-76149136972en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage30en_US
dc.identifier.urihttps://doi.org/10.1097/MJT.0b013e318197eec6
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11934
dc.identifier.volume17en_US
dc.identifier.wosWOS:000273849000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAmerican Journal of Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectQTc intervalen_US
dc.subjecttricyclic antidepressantsen_US
dc.subjectselective serotonin reuptake inhibitorsen_US
dc.titleQTc Intervals in Drug Poisoning Patients with Tricyclic Antidepressants and Selective Serotonin Reuptake Inhibitorsen_US
dc.typeArticleen_US

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