Effects of ebselen on ischemia/reperfusion injury in rat brain

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dc.authoridMEYDAN, SEDAT/0000-0002-1393-3235
dc.authoridUlutas, Kemal Turker/0000-0003-2852-0449
dc.contributor.authorAras, M.
dc.contributor.authorAltas, M.
dc.contributor.authorMeydan, S.
dc.contributor.authorNacar, E.
dc.contributor.authorKarcioglu, M.
dc.contributor.authorUlutas, K. T.
dc.contributor.authorSerarslan, Y.
dc.date.accessioned2024-09-18T20:16:37Z
dc.date.available2024-09-18T20:16:37Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Interruption of blood flow may result in considerable tissue damage via ischemia/reperfusion (I/R) injury-induced oxidative stress in brain tissues. The aim of the present study was to investigate the effects of Ebselen treatment in short-term global brain I/R injury in rats. Material and Methods: The study was carried out on 27 Wistar-albino rats, divided into three groups including Sham group (n = 11), I/R group (n = 8) and I/R+Ebselen group (n = 8). Results: Malondialdehyde (MDA) levels were significantly increased in I/R group in comparison with the Sham group and I/R+Ebselen group (p < 0.001 and p < 0.01). Superoxide dismutase (SOD) activity was significantly lower in I/R group in comparison to both Sham (p < 0.001) and I/R+Ebselen (p < 0.01) groups. Similarly, SOD activity was decreased in I/R+Ebselen group when compared with Sham group (p < 0.001). Sham and I/R groups were similar in terms of nitric oxide (NO) levels. In contrast, the NO level was lower in I/R+Ebselen group when compared with Sham (p < 0.001) and I/R (p < 0.01) groups. There was no significant difference among the groups in terms of glutathione peroxidase and catalase activities. In histopathological examination, the brain tissues of rats that received Ebselen showed morphological improvement. Conclusion: Ebselen has neuron-protective effects due to its antioxidant properties as shown by the decrease in MDA overproduction, increase in SOD activity and the histological improvement after administration of Ebselen to I/R in brain tissue.en_US
dc.identifier.doi10.3109/00207454.2013.879581
dc.identifier.endpage776en_US
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.issue10en_US
dc.identifier.pmid24405262en_US
dc.identifier.scopus2-s2.0-84907062460en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage771en_US
dc.identifier.urihttps://doi.org/10.3109/00207454.2013.879581
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9643
dc.identifier.volume124en_US
dc.identifier.wosWOS:000341774700009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEbselenen_US
dc.subjectbrain injuryen_US
dc.subjectischemiaen_US
dc.subjectreperfusionen_US
dc.titleEffects of ebselen on ischemia/reperfusion injury in rat brainen_US
dc.typeArticleen_US

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