Synergistic activities of two propolis with amphotericin B against some azole-resistant candida strains. Part II

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dc.authorscopusid35612683100
dc.authorscopusid42062060600
dc.authorscopusid59158928900
dc.authorscopusid7004087924
dc.authorscopusid8927152600
dc.contributor.authorNizami, Duran
dc.contributor.authorMustafa, Muz
dc.contributor.authorGulbol, Duran Gulay
dc.contributor.authorBurcin, Ozer
dc.contributor.authorYusuf, Onlen
dc.date.accessioned2024-09-19T15:41:15Z
dc.date.available2024-09-19T15:41:15Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.descriptionS.C. Pielorex S.A.; S.C. Prodstefano S.R.L.; S.C. Taro Industry S.A.; S.C. Hofigal Export-Import S.A.; S.C. Class Shoe S.R.L.en_US
dc.description3rd International Conference on Advanced Materials and Systems, ICAMS 2010 -- 16 September 2010 through 18 September 2010 -- Bucharest -- 85353en_US
dc.description.abstractCandida strains are opportunistic pathogenic fungi in humans which can cause either septicaemic or mucosal infections In this study, we aimed to investigate the existance of synergistic activities of two types of propolis (Hatay and Bursa) with Amphotericin B against some azole-resistant Candida strains. To evaluate cytotoxicity of propolis for human cells, the HEp-2 cell line (human larynx epidermoid carcinoma cell line) was used. The cytotoxicity of propolis samples was determined on a conventional haemocytometer using the trypan blue exclusion method. The synergystic activity of Hatay and Bursa propolis samples was assayed against four different azole-resistant Candida isolates (C. albicans, C. tropicalis, C. parapsilosis and C.glabrata). MIC values of Candida spp. were determined as described in the CLSI reference methods. The antifungal activities of a combination of this antifungal agent (Amphotericin B) were assessed by the checkerboard test and time-kill curve study. Bursa and Hatay propolis samples have remarkable antifungal activity against C.albicans, C.glabrata, C.tropicalis and C.parapsilosis. Also, the strong synergistic activity between Amphotericin B and propolis (especially Bursa propolis) was found against the azole resistant Candida strains. Propolis may be an important prospect in the treatment of azole-resistant yeast. The effects of these two kinds of propolis against the Candida spp. in vitro are promising.en_US
dc.identifier.endpage222en_US
dc.identifier.scopus2-s2.0-79959837045en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14118
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofProceedings of the 3rd International Conference on Advanced Materials and Systems, ICAMS 2010en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmphotericin Ben_US
dc.subjectCandida strainsen_US
dc.subjectPropolisen_US
dc.titleSynergistic activities of two propolis with amphotericin B against some azole-resistant candida strains. Part IIen_US
dc.typeConference Objecten_US

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