Expressions of TRPM6 and TRPM7 and histopathological evaluation of tissues in ischemia reperfusion performed rats

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dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridbozgeyik, ibrahim/0000-0003-1483-2580
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorGogebakan, Bulent
dc.contributor.authorYumrutas, Onder
dc.contributor.authorBozgeyik, Ibrahim
dc.contributor.authorGokce, Hasan
dc.contributor.authorDemir, Tuncer
dc.date.accessioned2024-09-18T20:06:22Z
dc.date.available2024-09-18T20:06:22Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThere is very little work on the expression of TRPM6/7 in ischemia reperfusion models. In previous studies, after ischemia, reperfusion had been kept limited to 24 h, yet in our study, expressions of these channels were elucidated after its modification to 48 h to establish what kind of changes renal tissues undergo. For the current study, 20 Wistar albino rats were divided into two groups equally. Group I: control group, Group II = I/R group (60 min ischemia + 48 h reperfusion). For the mRNA analysis, right kidneys of I/R group was used as a reference in order to eliminate genetic differences. The left renal artery (I/R generated part) of I/R area was removed from all rats in the second group. Likewise, normal tissues of right renal artery were removed from all rats. Histopathologic scoring of the tissue samples were achieved semi-quantitatively according to normal tissue composition. Consequently, both TRPM6 and TRPM7 expression levels were decreased in all groups according to control groups, yet results were not counted as significant (p>0.05). Additionally, correlation analysis confirmed these results. Also, I/R performed kidneys had more tissue damage compared to control group. To conclude, our study results suggest that TRPM6/7 expressions may be increased and after 48 h of reperfusion expression levels of these two stored to normal levels. At the same time, damages have occurred in renal tissues after ischemia. These damages were considered to be resulted from the oxidative effects as previously reported.en_US
dc.identifier.doi10.3109/0886022X.2014.900405
dc.identifier.endpage936en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue6en_US
dc.identifier.pmid24679001en_US
dc.identifier.scopus2-s2.0-84903269287en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage932en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2014.900405
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8490
dc.identifier.volume36en_US
dc.identifier.wosWOS:000337949800018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCalciumen_US
dc.subjectIschemia/reperfusionen_US
dc.subjectmagnesiumen_US
dc.subjectTRPM channelsen_US
dc.titleExpressions of TRPM6 and TRPM7 and histopathological evaluation of tissues in ischemia reperfusion performed ratsen_US
dc.typeArticleen_US

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