Effects of acute hypoxia on left and right ventricular contractility in chronic obstructive pulmonary disease

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dc.authorscopusid35952912800
dc.authorscopusid7004607065
dc.authorscopusid6507940559
dc.authorscopusid6602176611
dc.contributor.authorAkgül, Ferit
dc.contributor.authorBatyraliev, Talantbek
dc.contributor.authorKarben, Zarema
dc.contributor.authorPershukov, Igor
dc.date.accessioned2024-09-19T15:41:24Z
dc.date.available2024-09-19T15:41:24Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe purpose of this investigation was to assess the effects of acute hypoxia on left (LV) and right ventricular (RV) contractility in clinically stable chronic obstructive pulmonary disease (COPD) patients. Eleven male patients (mean age 52.4 ± 12.6 years) who were diagnosed to have COPD were included into the study. All of the patients underwent left and right heart catheterization. RV contractility was measured according to the method of Ferlinz and LV contractility according to the method of Kennedy and colleagues using indirect digital substraction angiography. Mean pulmonary artery pressures (Mean PPA) and oxygen saturation of the pulmonary artery (SaO2) were measured before and at each stage of graded hypoxic exposure 14%, 12%, and 10% of O2. Right atrial pressures (PRA,syst, PRA,diast, PRA,mean), RV pressures (PRV,syst, PRV,diast, PRV,mean, PRV,end-diast), RV and LV end-diastolic volume index (EDVI), end-systolic volume index (ESVI), stroke volume index (SVI), cardiac index (CI), ejection fraction (EF), and heart rate (HR) were calculated before and after breathing a hypoxic mixture of 10% of O2 for 30 minutes. Acute hypoxia induced significant elevation of mean PPA, PRA,syst, PRA,diast, PRA,mean, PRV,syst, PRV,mean, PRV,end-diast, RV EDVI, RV ESVI, LV EDVI, LV ESVI, confidence interval, and HR (p<0.05). Whereas SaO2 decreased significantly after acute hypoxia (p<0.05). These findings suggest that the systolic performance of the fight and left ventricles were well-maintained during acute hypoxia in patients with COPD. © 2007 Dove Medical Press Limited. All rights reserved.en_US
dc.identifier.doi10.2147/copd.2007.2.1.77
dc.identifier.endpage80en_US
dc.identifier.issn1176-9106
dc.identifier.issue1en_US
dc.identifier.pmid18044069en_US
dc.identifier.scopus2-s2.0-34250360753en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.2147/copd.2007.2.1.77
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14241
dc.identifier.volume2en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofInternational Journal of COPDen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute hypoxiaen_US
dc.subjectObstructive pulmonary diseaseen_US
dc.subjectVentricular contractilityen_US
dc.titleEffects of acute hypoxia on left and right ventricular contractility in chronic obstructive pulmonary diseaseen_US
dc.typeArticleen_US

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