The Role of Trigeminal Ganglion Neuron Density in the Prevention of Subarachnoid Hemorrhage-induced Basilar Artery Vasospasm: An Experimental Study

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dc.authoridGundogdu, Cemal/0000-0003-2857-923X
dc.authoridRECEP, AYGUL/0000-0002-3603-2480
dc.authoridKOTAN, DILCAN/0000-0002-3101-4742
dc.contributor.authorOnder, Arif
dc.contributor.authorSerarslan, Yurdal
dc.contributor.authorAydin, Mehmet Dumlu
dc.contributor.authorAydin, Nazan
dc.contributor.authorUlvi, Hizir
dc.contributor.authorKotan, Dilcan
dc.contributor.authorAygul, Recep
dc.date.accessioned2024-09-18T21:00:23Z
dc.date.available2024-09-18T21:00:23Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Cerebral arteries innervated by several systems contribute to the control of cerebral blood flow. Sensory fibers of the trigeminal nerve have a vasodilatory effect on the basilar artery. Subarachnoid hemorrhage (SAH) causes severe cerebral vasospasm by various neurochemical mechanisms. We examined possible relationships between the neuron density of the trigeminal ganglion and the severity of basilar artery vasospasm in SAH. Methods: In this study, 28 rabbits were used. The animals were randomly divided into 3 groups: SAH (n = 18), serum physiologic (n = 5) and control (n = 5) groups. Experimental SAH was induced by injecting homologous blood into the cisterna magna. After 20 days, the basilar arteries and trigeminal ganglions were examined histopathologically. Basilar artery volumes and the neuron density of the ophthalmic divisions of the trigeminal ganglions were estimated stereologically, and the results were statistically analyzed. Results: The mean basilar artery volume was 4.15 +/- 0.19 mm(3) and the mean neuronal density of the trigeminal ganglion was 6500 +/- 750/mm(3) for the control group. These values were 4.05 +/- 0.29 mm(3) and 6400 +/- 584/mm(3) for the serum physiologic group, 3.80 +/- 0.35 mm(3) and 4600 +/- 300/mm(3) for living animals in the SAH group, and 2.26 +/- 0.29 mm(3) and 2950 +/- 618/mm(3) for dead animals in SAH group, respectively. A linear relationship was found between the neuronal density of the trigeminal ganglion and basilar artery volumes. Conclusions: The neuron density of the trigeminal ganglion may be an important factor in the regulation of basilar artery volume and for the continuation of cerebral blood flow. The low neuron density of the trigeminal ganglion may be involved in the pathogenesis of severe basilar artery vasospasm induced by SAH.en_US
dc.identifier.endpage269en_US
dc.identifier.issn1050-6438
dc.identifier.issn1534-4916
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-74949087456en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage264en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12649
dc.identifier.volume19en_US
dc.identifier.wosWOS:000272116000008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNeurosurgery Quarterlyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecttrigeminal ganglionen_US
dc.subjectneuron densityen_US
dc.subjectbasilar arteryen_US
dc.subjectvasospasmen_US
dc.subjectSAHen_US
dc.subjectsubarachnoid hemorrhageen_US
dc.titleThe Role of Trigeminal Ganglion Neuron Density in the Prevention of Subarachnoid Hemorrhage-induced Basilar Artery Vasospasm: An Experimental Studyen_US
dc.typeArticleen_US

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