IMMUNOHISTOCHEMICAL INVESTIGATION OF ENDOMETRIAL LEUKOCYTES IN IMPLANTATION PERIOD IN RATS WITH STREPTOZOTOSIN-INDUCED DIABETES

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dc.contributor.authorNacar, Emel
dc.contributor.authorBozkurt, Yesim Akaydin
dc.contributor.authorKoc, Ahmet
dc.contributor.authorNacar, Ahmet
dc.date.accessioned2024-09-18T20:28:06Z
dc.date.available2024-09-18T20:28:06Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOur first aim was to determine the total leukocyte profile in implantation. Second aim was to detect the changes in uterine leukocyte profile in diabetes, a common accompanying disease. For this purpose 4 groups are formed with Wistar albino rats weighing 250-300 g. Two of the groups were non-diabetic and two of them were diabetic. One of the diabetic and one of the non-diabetic groups were left pregnant. Then uterus tissues of pregnant animals were removed in the 5th and 7th days of pregnancy together with tissues of other two non-pregnant groups. Tissues were analyzed immunohistochemically with antibodies CD45, CD3, CD4, CD8, CD56, CD68 and CD79a. It was revealed that pregnancy increased immune staining of CD68, CD3, CD45 and CD56 in endometrium. In addition it was observed that immune staining density of CD68, CD45 and CD56 decreased in diabetes. In the histopathological examination, significant degeneration was detected in the endometrium of diabetic rats. Diabetes could decrease leukocyte proportions in decidua in early pregnancy periods. Therefore immune cell therapies could be administrated in diabetes related problems of pregnancy.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Projects Unit [1004 D 0105]en_US
dc.description.sponsorshipThis study was supported by Mustafa Kemal University Scientific Projects Unit with Project Number 1004 D 0105.en_US
dc.identifier.doi10.5114/PJP.2016.59191
dc.identifier.endpage59en_US
dc.identifier.issn1233-9687
dc.identifier.issue1en_US
dc.identifier.pmid27179275en_US
dc.identifier.scopus2-s2.0-84966687266en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.5114/PJP.2016.59191
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10737
dc.identifier.volume67en_US
dc.identifier.wosWOS:000375804800010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVesalius Univ Medical Publen_US
dc.relation.ispartofPolish Journal of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectimplantationen_US
dc.subjectdiabetesen_US
dc.subjectendometriumen_US
dc.subjectimmunohistochemistryen_US
dc.subjectraten_US
dc.subjectimmune cellsen_US
dc.titleIMMUNOHISTOCHEMICAL INVESTIGATION OF ENDOMETRIAL LEUKOCYTES IN IMPLANTATION PERIOD IN RATS WITH STREPTOZOTOSIN-INDUCED DIABETESen_US
dc.typeArticleen_US

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