Serum antioxidant activities, malondialdehyde and nitric oxide levels in human cutaneous leishmaniasis

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dc.contributor.authorSerarslan, G
dc.contributor.authorYilmaz, HR
dc.contributor.authorSögüt, S
dc.date.accessioned2024-09-18T21:05:15Z
dc.date.available2024-09-18T21:05:15Z
dc.date.issued2005
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractLeishmania sp. are obligate intracellular protozoa that infect and replicate within mammalian macrophages. Macrophages, neutrophils and other phagocytic cells are key components of the antimicrobial and tumoricidal immune responses. These cells are capable of generating large amounts of reactive oxygen species (ROS) and reactive nitrogen species (RNS). To examine antioxidant status and lipid peroxidation in cutaneous leishmaniasis (CL) patients, activities of two ROS scavenging enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the levels of malondialdehyde (MDA) and nitric oxide (NO.) have been studied in serum. Blood samples were taken from CL patients before treatment (n = 27) and after the treatment (n = 18). NO. and MDA levels, SOD and GSH-Px activities were compared between untreated and treated CL patients and control subjects (n = 23). There was a significant decrease in SOD and GSH-Px activities in the CL patients (P < 0.0001). Significantly higher levels of serum MDA and NO. levels were found in CL patients, compared to controls and treated patients. It may be suggested that the overproduction of ROS and RNS results in oxidative stress and the acceleration of lipid peroxidation in CL patients, resulting from altered enzymatic antioxidant activities.en_US
dc.identifier.doi10.1111/j.1365-2230.2005.01758.x
dc.identifier.endpage271en_US
dc.identifier.issn0307-6938
dc.identifier.issue3en_US
dc.identifier.pmid15807687en_US
dc.identifier.scopus2-s2.0-17444422846en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.1111/j.1365-2230.2005.01758.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13473
dc.identifier.volume30en_US
dc.identifier.wosWOS:000228049400017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofClinical and Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlutathione-Peroxidaseen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectReactive Nitrogenen_US
dc.subjectEnzyme-Activitiesen_US
dc.subjectL-Arginineen_US
dc.subjectOxygenen_US
dc.subjectPhagocytosisen_US
dc.subjectMacrophagesen_US
dc.subjectMechanismen_US
dc.subjectImiquimoden_US
dc.titleSerum antioxidant activities, malondialdehyde and nitric oxide levels in human cutaneous leishmaniasisen_US
dc.typeArticleen_US

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