Comparison of azithromycin and a combination of trypsin, chymotrypsin and papain proteolytic enzymes for the treatment of bovine cutaneous papillomatosis

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dc.authoridOzsoy, Sule Yurdagul/0000-0003-4254-7146
dc.contributor.authorDeveci, Mehmet Zeki Yilmaz
dc.contributor.authorAltus, Muhammed Enes
dc.contributor.authorAlaku, Halil
dc.contributor.authorOzsoy, Sule Yurdagul
dc.date.accessioned2024-09-18T20:08:06Z
dc.date.available2024-09-18T20:08:06Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAlthough various methods have been used in the treatment of bovine cutaneous papillomatosis (BCP), no definite treatment has yet been established. There are no studies regarding the efficacy of azithromycin (AZ) and of any combination of trypsin, chymotrypsin, and papain proteolytic enzymes (PEC) in the treatment of BCP. The objective of this study was to investigate the efficacy of AZ and PEC in the treatment of BCP. A total of 24 female Holstein cattle of 6-17 months of age with spontaneous BCP were used for this study. In addition to the clinical findings, the diagnosis was confirmed with histopathological examinations. The animals were divided at random into three groups (n = 8). The AZ group received 10 mg/kg/day PO for 10 days. In the PEC group, an injectable suspension of proteolytic enzymes was applied IM at 0.4 mL/10 kg dose, 3 times with 8-10 days interval and the spray was used topically once a day for 10 days. The control group (CO) was not treated. The mean in papilloma warts decreased 92.4 % in the AZ group, 83.38 % in the PEC group, and 59.48 % in the CO. There were statistically significant differences in warts presence decreases between the three groups (P < 0.05). Both AZ and PEC were considered successful for the BCP treatment. However, AZ was found more effective than PEC.en_US
dc.description.sponsorshipCoordinatorship of Scientific Research Projects of Hatay Mustafa Kemal University [17]en_US
dc.description.sponsorshipThis work was supported by the Coordinatorship of Scientific Research Projects of Hatay Mustafa Kemal University, (Project number: 17.YL.002).en_US
dc.identifier.doi10.22201/fmvz.24486760e.2022.888
dc.identifier.issn0301-5092
dc.identifier.issn2448-6760
dc.identifier.scopus2-s2.0-85132928928en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.22201/fmvz.24486760e.2022.888
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8630
dc.identifier.volume9en_US
dc.identifier.wosWOS:000858595900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Nacional Autonoma Mexico Facultad Medicina Veterinaria Zootecniaen_US
dc.relation.ispartofVeterinaria Mexicoen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcattleen_US
dc.subjectherden_US
dc.subjectpapillomavirusen_US
dc.subjectskinen_US
dc.subjectwarten_US
dc.titleComparison of azithromycin and a combination of trypsin, chymotrypsin and papain proteolytic enzymes for the treatment of bovine cutaneous papillomatosisen_US
dc.typeArticleen_US

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