ATTENUATING EFFECTS OF CAFFEIC ACID PHENETHYL ESTER WITH INTRALIPID ON HEPATOTOXICITY OF CHLORPYRIFOS IN THE CASE OF RATS

Basit Öğe Kaydı
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorBilgili, Ali
dc.contributor.authorHanedan, Basak
dc.contributor.authorDogan, Hatice
dc.contributor.authorDokuyucu, Ahmet
dc.contributor.authorCelik, Muhammet Murat
dc.date.accessioned2024-09-18T20:02:34Z
dc.date.available2024-09-18T20:02:34Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Chlorpyrifos (CPF), insecticide widely used in agriculture, may cause poisonings in the case of humans. As a result, there is a large amount of treatment research underway to focus on the possibility of chlorpyrifos induced poisonings. The aim of this study has been to evaluate the effects of caffeic acid phenethyl ester (CAPE) and intralipid (IL) on hepatotoxicity induced by chlorpyrifos in the case of rats. Material and Methods: The rats in this study were treated with CPF (10 mg/kg body weight (b.w.), orally), CAPE (10 mu mol/kg b.w., intraperitoneally), IL (18.6 ml/kg b.w., orally), CPF+CAPE, CPF+IL, and CPF+CAPE+IL. The plasma total oxidant capacity (TOC), total antioxidant capacity (TAC) were measured and the oxidative stress index (OSI) was calculated. Liver histopathology and immunohistochemical staining were performed. Results: Chlorpyrifos statistically significantly decreased the TAC levels in the rats' plasma and increased the apoptosis and the TOC and OSI levels. In the chlorpyrifos induced liver injury, CAPE and CAPE+IL significantly decreased the plasma OSI levels and the apoptosis, and significantly increased the plasma TAC levels. Conclusions: This study revealed that CAPE and CAPE+IL attenuate chlorpyrifos induced liver injuries by decreasing oxidative stress and apoptosis.en_US
dc.identifier.doi10.13075/mp.5893.00462
dc.identifier.endpage749en_US
dc.identifier.issn0465-5893
dc.identifier.issn2353-1339
dc.identifier.issue6en_US
dc.identifier.pmid28005083en_US
dc.identifier.scopus2-s2.0-85015356296en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage743en_US
dc.identifier.urihttps://doi.org/10.13075/mp.5893.00462
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7878
dc.identifier.volume67en_US
dc.identifier.wosWOS:000392121300004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNofer Inst Occupational Medicine, Polanden_US
dc.relation.ispartofMedycyna Pracyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectapoptosisen_US
dc.subjectoxidative stressen_US
dc.subjectliveren_US
dc.subjectratsen_US
dc.subjectchlorpyrifosen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.titleATTENUATING EFFECTS OF CAFFEIC ACID PHENETHYL ESTER WITH INTRALIPID ON HEPATOTOXICITY OF CHLORPYRIFOS IN THE CASE OF RATSen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
7878.pdf
Boyut:
466.31 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu