Biochemical compounds and their antimicrobial activities in epidermal mucus obtained from two ray species Dasyatis pastinaca and Raja miraletus

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dc.authoridUyan, Ali/0000-0001-9308-3324
dc.contributor.authorUyan, Ali
dc.contributor.authorTuran, Cemal
dc.contributor.authorErdogan, Elif Ayse
dc.contributor.authorSangun, Mustafa Kemal
dc.date.accessioned2024-09-18T20:59:07Z
dc.date.available2024-09-18T20:59:07Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe epidermal mucus of two ray species Dasyatis pastinaca and Raja miraletus was analyzed to identify biochemical compounds and explore their antimicrobial activities in order to point out their potential for human health-related applications. Epidermal mucus samples were extracted as acidic, crude and aqueous. Gas chromatography and gas chromatography-mass spectrometry (GC/MS) analyses were performed to determine the biochemical compounds of the mucus. The antibacterial and antifungal activities of the extracts obtained from mucus were analysed using the spectrophotometric broth microdilution method against bacterial (Escherichia coli, Klebsiella pneumoniae, Bacillus subtilis and Enterococcus faecalis) and fungal (Candida albicans and Candida parapsilosis) strains. Gas chromatography and gas chromatography-mass spectrometry (GC/MS) analyses revealed the existence of several hydrocarbon-derived compounds and polycyclic aromatic hydrocarbons. In terms of antimicrobial activity, the highest detected MIC (minimum inhibitory concentration) value was 9.78 mu L for the acidic extract of R. miraletus epidermal mucus (RmAC) against E. faecalis, while the lowest MIC value was 80.88 mu L for the acidic extract of R. miraletus epidermal mucus (RmAC) against E. coli. The extracts of epidermal mucus from D. pastinaca and R. miraletus showed antimicrobial activities against all the used pathogens with varying degrees of efficiency and thus may be evaluated as a potential source of marine-derived antimicrobial components for biomedical purposes. gazeuse et chromatographie en phase gazeuse-spectrometrie de masse (GC/MS) ont revele l'existence de plusieurs composes derives d'hydrocarbures et d'hydrocarbures aromatiques polycycliques. Pour l'analyse antimicrobienne, la valeur MIC (minimum inhibitory concentration) la plus elevee detectee etait de 9,78 mu L pour l'extrait acide de mucus epidermique de R. miraletus (RmAC) contre E. faecalis, tandis que la valeur MIC la plus basse etait de 80,88 mu L pour l'extrait acide de mucus epidermique de R. miraletus (RmAC) contre E. coli. Les extraits de mucus epidermique de D. pastinaca et R. miraletus ont neanmoins montre des activites antimicrobiennes contre tous les agents pathogenes utilises avec divers degres d'efficacite et peuvent donc etre consideres comme une source potentielle de composants antimicrobiens d'origine marine a des fins biomedicales.en_US
dc.description.sponsorshipScientific & Technological Research Council of Turkey (TUBITAK-2211/C National Ph.D.); (Scholarship Program for Priority Areas)en_US
dc.description.sponsorshipThis study is generated from Dr. A. Uyan's Ph.D. Thesis. Thanks to the Scientific & Technological Research Council of Turkey (TUBITAK-2211/C National Ph.D. Scholarship Program for Priority Areas) for support.en_US
dc.identifier.doi10.21411/CBM.A.368DB6F6
dc.identifier.endpage330en_US
dc.identifier.issn0007-9723
dc.identifier.issn2262-3094
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85127467106en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage321en_US
dc.identifier.urihttps://doi.org/10.21411/CBM.A.368DB6F6
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12381
dc.identifier.volume62en_US
dc.identifier.wosWOS:000718969600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCahiers De Biologie Marineen_US
dc.relation.ispartofCahiers De Biologie Marineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStingraysen_US
dc.subjectSkatesen_US
dc.subjectEpidermalen_US
dc.subjectMucusen_US
dc.subjectBiochemical compoundsen_US
dc.subjectAntimicrobial propertiesen_US
dc.titleBiochemical compounds and their antimicrobial activities in epidermal mucus obtained from two ray species Dasyatis pastinaca and Raja miraletusen_US
dc.typeArticleen_US

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