Relationship between human platelet antigen-1 gene polymorphism and clopidogrel resistance in patients with coronary artery disease

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dc.authoridAKGUN, Taylan/0000-0002-5395-2027
dc.authoridTanboga, Ibrahim Halil/0000-0003-4546-9227
dc.contributor.authorTanboga, Ibrahim Halil
dc.contributor.authorCan, Mehmet Mustafa
dc.contributor.authorOzkan, Alper
dc.contributor.authorTokgoz, Hacer Ceren
dc.contributor.authorAkgun, Taylan
dc.contributor.authorKoca, Fatih
dc.contributor.authorKurt, Mustafa
dc.date.accessioned2024-09-18T19:54:21Z
dc.date.available2024-09-18T19:54:21Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: It has been proposed that human platelet antigen-1 (HPA-1) gene polymorphism is associated with coronary artery disease (CAD) and affects platelet function. We aimed to investigate the distribution of HPA gene polymorphism between angiographic CAD and a control group and the relation between HPA gene polymorphism and platelet aggregation. Study design: The study population consisted of 94 patients with angiographic CAD and 115 patients without angiographic CAD. Platelet aggregation was measured with impedance aggregometry on the fifth day of percutaneous coronary intervention (PCI). Platelet aggregation >480 AU/min was defined as the clopidogrel resistance. Blood samples were obtained from all participants at discharge for the analysis of HPA-1 gene polymorphism. Results: There was no significant difference in the distribution of HPA-1 gene polymorphism between the control and CAD groups (78.7% vs. 78.1% for A allele and 21.3% vs. 21.9% for B allele, p=NS). The analysis between groups with and without clopidogrel resistance revealed no significant difference in the distribution of HPA-1A and HPA-1B alleles between the groups (A allele 78.7% vs. 78.9% and B allele 21.3% vs. 21.1%, p=NS). In the CAD group, there were no significant differences in platelet aggregation between HPA-1A and HPA-1B alleles (294 +/- 240 vs. 259 +/- 261 AU/min, p=NS). Conclusion: Distribution of HPA-1 gene polymorphism was not different in CAD patients compared to the control group. HPA-1 gene polymorphism was not associated with platelet aggregation or clopidogrel resistance assessed by impedance aggregometry in the CAD group.en_US
dc.identifier.doi10.5543/tkda.2013.97253
dc.identifier.endpageU25en_US
dc.identifier.issn1016-5169
dc.identifier.issue5en_US
dc.identifier.pmid23917001en_US
dc.identifier.scopus2-s2.0-84881222083en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2013.97253
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7687
dc.identifier.volume41en_US
dc.identifier.wosWOS:000421896700002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngioplastyen_US
dc.subjectballoonen_US
dc.subjectcoronary/methodsen_US
dc.subjectdose-response relationshipen_US
dc.subjectdrugen_US
dc.subjectdrug resistanceen_US
dc.subjecthuman platelet antigen-1en_US
dc.subjectclopidogrelen_US
dc.subjectpercutaneous coronary interventionen_US
dc.subjectpolymorphismen_US
dc.subjectgeneticen_US
dc.subjectplatelet aggregation/drug effects/geneticsen_US
dc.titleRelationship between human platelet antigen-1 gene polymorphism and clopidogrel resistance in patients with coronary artery diseaseen_US
dc.typeArticleen_US

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