Protective Effects of Colchicine on Testicular Torsion/Detorsion-Induced Ischemia/Reperfusion Injury in Rats

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dc.contributor.authorGozukara, Kerem Han
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorOzgur, Tumay
dc.contributor.authorKaya, Yusuf Selim
dc.contributor.authorTutuk, Okan
dc.date.accessioned2024-09-18T20:11:34Z
dc.date.available2024-09-18T20:11:34Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: To evaluate the short-term use of colchicine on preventing ischemia-reperfusion injury after surgery in an experimental animal model. Materials and Methods: A total of 40 rats were divided into five groups (n = 8). Sham (Sh), ischemia-reperfusion (I/R), I/R and colchicine-treated for once per-operatively (I/Rcl), I/R and colchicine-treated for 5 days postoperatively (I/Rc5), and I/R and placebo given for 5 days (I/Rp) groups. Testicular torsion was created by rotating the testicle 720o in clockwise direction and held for 3 hours. In group I/Rcl 30 minutes before detorsion, p.o. 1 mg/kg mL infusion of colchicine was given only once. In group I/Rc5, colchicine continued p.o. once daily for five days. Tissue malonyldialdehite (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured for evaluating the oxidative stress. Apoptosis levels shown with Caspase-3 staining and mean seminiferous tubular diameter (MSTD), germinal epithelial cell thickness (GECT), and mean testicular biopsy score (MTBS) were used to evaluate the germ cell damage. Results: Decreased protein MDA levels therewithal increased SOD, CAT and GPx levels achieved in I/Rc5 group when compared to I/R group and did not differ from the I/Rp group (p < 0.05). MSTD, GECT, and JS were better in I/Rc5 than I/Rp which showed the natural course of I/R damage in testis (p < 0.005). Caspase 3 positivity, as an apoptosis indicator, were significantly lower (p < 0.05) in I/Rc5 group in comparison with I/R, I/Rcl, and I/Rp groups. Conclusion: The usage of colchicine as a complementary treatment after definitive surgery reduce early-onset ischemia-reperfusion damage and diminishes apoptosis.en_US
dc.identifier.doi10.22037/uj.v0i0.4918
dc.identifier.endpage300en_US
dc.identifier.issn1735-1308
dc.identifier.issn1735-546X
dc.identifier.issue3en_US
dc.identifier.pmid31364099en_US
dc.identifier.scopus2-s2.0-85085265758en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage294en_US
dc.identifier.urihttps://doi.org/10.22037/uj.v0i0.4918
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8949
dc.identifier.volume17en_US
dc.identifier.wosWOS:000535760900015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUrol & Nephrol Res Ctr-Unrcen_US
dc.relation.ispartofUrology Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcolchicineen_US
dc.subjectperfusionen_US
dc.subjectinjuryen_US
dc.subjectraten_US
dc.subjecttorsionen_US
dc.titleProtective Effects of Colchicine on Testicular Torsion/Detorsion-Induced Ischemia/Reperfusion Injury in Ratsen_US
dc.typeArticleen_US

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