Comparison of 24-Hour Electrocardiogram Parameters in Patients with Graves' Disease Before and After Anti-Thyroid Therapy

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dc.authoridBEKLER, OZKAN/0000-0002-0031-6457
dc.authoridakkus, oguz/0000-0001-7988-7027
dc.contributor.authorAkkus, Gamze
dc.contributor.authorSokmen, Yeliz
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorBekler, Ozkan
dc.contributor.authorAkkus, Oguz
dc.date.accessioned2024-09-18T20:59:27Z
dc.date.available2024-09-18T20:59:27Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: We aimed prospectively to investigate the laboratory and electrocardiographic parameters (heart rate, QRS, QT, QTc, Tpe, Tpe/QTc, and arrhythmia prevalence) in patients with Graves' disease before and after antithyroid therapy. Methods: Seventy-one patients (48 female, and 23 male), of age between 18-50 years (mean +/- SD: 36.48 +/- 12.20) with GD were included in the study. Patients were treated with antithyroid therapy (thioamides and/or surgical therapy) to maintain euthyroid status. Patients were examined in terms of electrocardiographic parameters before and after the treatment. Results: Mean TSH, free thyroxin (fT(4)), and tri-iodothyrionine (fT(3)) levels of all patients were 0.005 +/- 0.21, 3.27 +/- 1.81, 11.42 +/- 7.44, respectively. While 9 patients (group 2) underwent surgical therapy, had suspicious malignant nodule or large goiter, and unresponsiveness to medical treatment; the other patients (n=62, group 1) were treated with medical therapy. Patients with surgical therapy had more increased serum fT4 (p=0.045), anti-thyroglobulin value (p=0.018) and more severe graves orbitopathy (n=0.051) before treatment when compared to a medical therapy group. Baseline Tpe duration and baseline Tpe/QTc ratio and frequency of supraventricular ectopic beats were found to be significantly higher in group 2 when compared to group 1 (p=0.00, p=0.005). Otherwise, the baseline mean heart rate, QRS duration, QTc values of both groups were similar. Although the patients came at their euthyroid status, group 2 patients still suffered from more sustained supraventricular ectopics beats than group 1. Conclusion: Distinct from the medical treatment group, surgical treatment group with euthyroidism for at least 3 months still suffered from an arrhythmia (Tpe, Tpe/QTc, supraventricular and ventricular ectopic beats).en_US
dc.identifier.doi10.2174/1871530320666200729145100
dc.identifier.endpage191en_US
dc.identifier.issn1871-5303
dc.identifier.issn2212-3873
dc.identifier.issue1en_US
dc.identifier.pmid32727336en_US
dc.identifier.scopus2-s2.0-85101076855en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://doi.org/10.2174/1871530320666200729145100
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12580
dc.identifier.volume21en_US
dc.identifier.wosWOS:000613440100019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBentham Science Publ Ltden_US
dc.relation.ispartofEndocrine Metabolic & Immune Disorders-Drug Targetsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThyrotoxicosisen_US
dc.subjectarrhythmiaen_US
dc.subjectanti-thyroid therapyen_US
dc.subjectGraves' Diseaseen_US
dc.subjecthyperthyroidismen_US
dc.subjectelectrocardiogramen_US
dc.titleComparison of 24-Hour Electrocardiogram Parameters in Patients with Graves' Disease Before and After Anti-Thyroid Therapyen_US
dc.typeArticleen_US

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