The role of serum lipoxin A4 levels in the association between periodontal disease and metabolic syndrome

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dc.contributor.authorDogan, Esra Sinem Kemer
dc.contributor.authorDogan, Burak
dc.contributor.authorFentoglu, Ozlem
dc.contributor.authorKirzioglu, Fatma Yesim
dc.date.accessioned2024-09-18T20:27:59Z
dc.date.available2024-09-18T20:27:59Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: An unresolved inflammatory state contributes to the pathogenesis of periodontal disease and metabolic syndrome (MetS). Therefore, the purpose of this study was to evaluate the role of lipoxin A4 (LXA4), a proresolving lipid mediator, in the association between periodontal disease and MetS. Methods: Sixty-seven patients with MetS and 65 patients without MetS were included in the study. Sociodemographic information was obtained via a questionnaire, and detailed medical diagnoses were made. Periodontal parameters (plaque index [PI], gingival index [GI], probing pocket depth [PD], and clinical attachment level [CAL]) and metabolic parameters were measured, and serum LXA4 levels were determined. The associations among MetS, periodontal parameters, and serum LX levels were evaluated by adjusted multivariate linear regression analyses. Results: Patients with MetS were older and had a higher body mass index than patients without MetS. Periodontal parameters (PI, GI, PD, and CAL) were higher in patients with MetS than in those without MetS. Serum LXA4 levels were higher in patients without MetS. Multivariate linear regression analysis indicated a positive association between MetS and periodontal parameters (PD and CAL). Negative associations were established between MetS and LXA4 levels, and between LXA4 and periodontal parameters (PI, PD, and CAL). Conclusions: The presence of higher values of periodontal parameters in patients with MetS and the negative relationship of LXA4 with MetS and periodontal disease may support the protective role of proresolving lipid mediators in the association between periodontal disease and MetS.en_US
dc.identifier.doi10.5051/jpis.2019.49.2.105
dc.identifier.endpage113en_US
dc.identifier.issn2093-2278
dc.identifier.issn2093-2286
dc.identifier.issue2en_US
dc.identifier.pmid31098331en_US
dc.identifier.scopus2-s2.0-85065614941en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage105en_US
dc.identifier.urihttps://doi.org/10.5051/jpis.2019.49.2.105
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10656
dc.identifier.volume49en_US
dc.identifier.wosWOS:000466498800005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Acad Periodontologyen_US
dc.relation.ispartofJournal of Periodontal and Implant Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInflammationen_US
dc.subjectLipoxinsen_US
dc.subjectMetabolic syndrome Xen_US
dc.subjectPeriodontal diseasesen_US
dc.titleThe role of serum lipoxin A4 levels in the association between periodontal disease and metabolic syndromeen_US
dc.typeArticleen_US

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