Expression patterns of major genes in fatty acid synthesis, inflammation, oxidative stress pathways from colostrum to milk in Damascus goats

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dc.authoridDalkiran, Sevda/0000-0002-5704-5774
dc.authoridKaya, Ufuk/0000-0002-4805-0993
dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.contributor.authorYakan, Akin
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorCamdeviren, Baran
dc.contributor.authorKaya, Ufuk
dc.contributor.authorKaraaslan, Irem
dc.contributor.authorDalkiran, Sevda
dc.date.accessioned2024-09-18T21:05:04Z
dc.date.available2024-09-18T21:05:04Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe molecular regulation of milk secretion and quality in the transition period from colostrum to milk in goats is largely unknown. In the present study, mammary gland secretion of goats was collected in 0th, 4th, 7th, 14th and 28th days after parturition. In addition to composition and fatty acid profile of colostrum or milk, FASN, SCD, ACACA, COX-2, NRF2, TLR2, NF-kB, LTF and PTX3 genes expression patterns were determined from milk somatic cells. While somatic cell count (SCC), malondialdehyde (MDA), fat, fat-free dry matter, protein and lactose were highest as expression levels of the oxidative and inflammatory genes, freezing point and electrical conductivity were lowest in colostrum. With the continuation of lactation, most of the fatty acids, n3 ratio, and odour index increased but C14:0 and C16:0 decreased. While FASN was upregulated almost threefolds in 14th day, ACACA was upregulated more than fivefolds in 7th and 14th days. Separately, the major genes in fatty acid synthesis, inflammation and oxidative stress were significantly associated with each other due to being positively correlated. MDA was positively correlated with SCC and some of the genes related inflammation and oxidative stress. Furthermore, significant negative correlations were determined between SCC and fatty acid synthesis related genes. With this study, transition period of mammary secretion was particularly clarified at the molecular levels in Damascus goats.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [119O716]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) with the 119O716 project number.en_US
dc.identifier.doi10.1038/s41598-021-88976-0
dc.identifier.issn2045-2322
dc.identifier.issue1en_US
dc.identifier.pmid33941846en_US
dc.identifier.scopus2-s2.0-85105178083en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1038/s41598-021-88976-0
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13338
dc.identifier.volume11en_US
dc.identifier.wosWOS:000657422500038en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNature Portfolioen_US
dc.relation.ispartofScientific Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSomatic-Cell Counten_US
dc.subjectMammary-Glanden_US
dc.subjectLactationen_US
dc.subjectInfectionen_US
dc.subjectStageen_US
dc.subjectLactoferrinen_US
dc.subjectLipolysisen_US
dc.subjectNetworksen_US
dc.subjectProfileen_US
dc.subjectBreeden_US
dc.titleExpression patterns of major genes in fatty acid synthesis, inflammation, oxidative stress pathways from colostrum to milk in Damascus goatsen_US
dc.typeArticleen_US

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