Protective effect-of melatonin against formaldehyde-induced kidney damage in rats

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dc.authoridMEYDAN, SEDAT/0000-0002-1393-3235
dc.contributor.authorZararsiz, I.
dc.contributor.authorSarsilmaz, M.
dc.contributor.authorTas, U.
dc.contributor.authorKus, I.
dc.contributor.authorMeydan, S.
dc.contributor.authorOzan, E.
dc.date.accessioned2024-09-18T20:25:11Z
dc.date.available2024-09-18T20:25:11Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description10th National Anatomy Congress -- SEP 06-10, 2006 -- Bodrum, TURKEYen_US
dc.description.abstractThis study was undertaken to investigate the protective effects of melatonin against formaldehyde-induced renal damage in rats. For this purpose, 21 male Wistar rats were divided into three groups. The animals in Group I were used as a control, whereas the rats in group II were injected every other day with formaldehyde. The rats in group III received melatonin daily while exposed to formaldehyde. At the end of the 14-day experimental period, all rats were killed by decapitation, and the kidneys were removed. Some of the renal tissue specimens were used for determination of superoxide dismutase, glutatione peroxidase enzyme activities, and malondialdehyde levels. The remaining kidney tissue specimens were used for light microscopic evaluation. The renal tissue activities of superoxide dismutase and glutatione peroxidase were significantly decreased, and malondialdehyde levels were significantly increased in rats treated with formaldehyde compared with those of the control animals. In the light microscopic evaluation of this group, degenerative glomerules, vacuolization and dilatation of distal tubules, and vascular congestion were detected. However, an increase was observed in activities of superoxide dismutase and glutatione peroxidase enzymes, and a decrease of malondialdehyde levels in animals treated with formaldehyde plus melatonin was observed. Furthermore, the histopathological changes caused by formaldehyde were disappeared except for minimal tubular dilatation in this group. In conclusion, the biochemical and histological findings of our study suggest that melatonin administration prevents formaldehyde-induced oxidative renal damage in rats.en_US
dc.identifier.doi10.1177/0748233708089022
dc.identifier.endpage579en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue10en_US
dc.identifier.pmid18717515en_US
dc.identifier.scopus2-s2.0-46149102483en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage573en_US
dc.identifier.urihttps://doi.org/10.1177/0748233708089022
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10146
dc.identifier.volume23en_US
dc.identifier.wosWOS:000257363300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectformaldehydeen_US
dc.subjectmelatoninen_US
dc.subjectkidneyen_US
dc.subjectraten_US
dc.titleProtective effect-of melatonin against formaldehyde-induced kidney damage in ratsen_US
dc.typeConference Objecten_US

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