Nicotine, its metabolism and an overview of its biological effects

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dc.contributor.authorYildiz, D
dc.date.accessioned2024-09-18T20:52:45Z
dc.date.available2024-09-18T20:52:45Z
dc.date.issued2004
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractNicotine is a naturally occurring alkaloid found in many plants. The principal Sources of nicotine exposure is through the use of tobacco, nicotine containing gum and nicotine replacement therapies. Nicotine is an amine composed of pyridine and pyrrolidine rings. It has been shown that nicotine crosses biological membranes and the blood brain barrier easily. The absorbed nicotine is extensively metabolized in the liver to form a wide variety of metabolites including nicotine N-oxidc and cotinine A-oxide. These are the products of mixed function oxidase system. Nicotine is also converted to some biologically important compounds during harvesting. Among these are the nitrosamines specific to tobacco. Nicotine has been shown to affect a wide Variety of biological functions ranging front gene expression, regulation of hormone secretion and enzyme activities. The objective of this Study was to overview the biological effects and metabolism of nicotine. (C) 2004 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.toxicon.2004.01.017
dc.identifier.endpage632en_US
dc.identifier.issn0041-0101
dc.identifier.issue6en_US
dc.identifier.pmid15109883en_US
dc.identifier.scopus2-s2.0-1942532837en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage619en_US
dc.identifier.urihttps://doi.org/10.1016/j.toxicon.2004.01.017
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11366
dc.identifier.volume43en_US
dc.identifier.wosWOS:000221371500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofToxiconen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnicotineen_US
dc.subjectmetabolism of nicotineen_US
dc.subjecteffects of nicotineen_US
dc.titleNicotine, its metabolism and an overview of its biological effectsen_US
dc.typeReview Articleen_US

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