The genotoxic effects of perchloroethylene in human peripheral blood lymphocytes and the possible ameliorative role of ?-tocopherol

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dc.contributor.authorKocaman, Ayse Yavuz
dc.contributor.authorAsfuroglu, Kubra
dc.date.accessioned2024-09-18T20:54:09Z
dc.date.available2024-09-18T20:54:09Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPerchloroethylene (PCE), also known as tetrachloroethylene, is a commercially important chlorinated solvent commonly used in dry cleaning, textile processing, and metal degreasing industries. According to the available studies, the potential genotoxic impacts of this chlorinated solvent on human beings are still controversial. The present work was carried out to determine the genotoxic effects of PCE on human peripheral blood lymphocytes (PBLs) using chromosome aberrations (CAs) and cytokinesis-block micronucleus (CBMN) tests. Additionally, the antigenotoxic potential of alpha-tocopherol (alpha-Toc), a well-known antioxidant agent, on human lymphocytes treated with PCE in vitro was assessed. The cells were exposed for 48 h to PCE (25, 50, 100, and 150 mu g/mL) alone as well as in combination with alpha-Toc (100 mu g/mL). The findings of the study suggested that, relative to solvent control, PCE significantly increased the structural CA and MN formation for all concentrations. However, simultaneous treatment of PCE and alpha-Toc caused a significant reduction of CAs and MNi as compared to cultures treated with PCE alone. Besides, the results showed that PCE has cytotoxic effects on human PBLs as indicated by the significant decrease in mitotic index (MI) and nuclear division index (NDI). Nevertheless, the co-treatment of alpha-Toc with PCE did not reduce the cytotoxicity of PCE at a significant level. In conclusion, it can be suggested that PCE is genotoxic and cytotoxic in human PBLs, and alpha-Toc has an antigenotoxic effect on PCE-induced genotoxicity but has no significant effect on the cytotoxicity triggered by PCE.en_US
dc.description.sponsorshipHatay Mustafa Kemal University [18.YL.011]en_US
dc.description.sponsorshipWe would like to thank Hatay Mustafa Kemal University Research Fund for providing financial support to this project (Project No: 18.YL.011).en_US
dc.identifier.doi10.1007/s11356-021-13523-3
dc.identifier.endpage39586en_US
dc.identifier.issn0944-1344
dc.identifier.issn1614-7499
dc.identifier.issue29en_US
dc.identifier.pmid33763835en_US
dc.identifier.scopus2-s2.0-85103154375en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage39576en_US
dc.identifier.urihttps://doi.org/10.1007/s11356-021-13523-3
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11628
dc.identifier.volume28en_US
dc.identifier.wosWOS:000632309600009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEnvironmental Science and Pollution Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPerchloroethyleneen_US
dc.subject? -Tocopherolen_US
dc.subjectChromosome aberrationen_US
dc.subjectMicronucleusen_US
dc.subjectHuman peripheral blood lymphocytesen_US
dc.subjectIn vitroen_US
dc.titleThe genotoxic effects of perchloroethylene in human peripheral blood lymphocytes and the possible ameliorative role of ?-tocopherolen_US
dc.typeArticleen_US

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