Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?

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dc.authoridBAYRAMOGLU, AYSEGUL/0000-0001-8567-807X
dc.authoridColak, Ertugrul/0000-0003-3251-1043
dc.authoridGuler, Halil Ibrahim/0000-0002-7261-6790
dc.contributor.authorBayramoglu, Aysegul
dc.contributor.authorUrhan Kucuk, Meral
dc.contributor.authorGuler, Halil Ibrahim
dc.contributor.authorAbaci, Okay
dc.contributor.authorKucukkaya, Yunus
dc.contributor.authorColak, Ertugrul
dc.date.accessioned2024-09-18T20:19:52Z
dc.date.available2024-09-18T20:19:52Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe current study was conducted to determine whether there is a relation between hypertension and two different polymorphisms, including C1562T of the Matrix metalloproteinase-9 (MMP-9) gene and C677T of the methylenetetrahydrofolate reductase (MTHFR) gene. Genomic DNA obtained from 224 persons (125 patients with hypertension and 99 healthy controls) were used in the study. Polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism and electrophoresis. The results were statistically analyzed and were found to be statistically significant. The frequencies of the C1562T genotypes were found to be, in controls CC 75.8 % and CT 24.2 % and in patients CC 71.2 %, and CT 28.8 %. The frequencies of C677T genotype were found to be, in controls CC 56.6 %, CT 38.4 and TT 5.1 % in controls and in patients CC 52 %, CT 30.4 % and TT 17.6 %. In conclusion, we may suggest that there is no relation between the essential hypertension and C1562T polymorphism of MMP-9 gene; on the other hand C677T polymorphism (genotype TT) of MTHFR gene can be regarded as a genetic indicator for the development of essential hypertension.en_US
dc.identifier.doi10.1007/s10616-013-9665-0
dc.identifier.endpage122en_US
dc.identifier.issn0920-9069
dc.identifier.issn1573-0778
dc.identifier.issue1en_US
dc.identifier.pmid24254300en_US
dc.identifier.scopus2-s2.0-84887582242en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage115en_US
dc.identifier.urihttps://doi.org/10.1007/s10616-013-9665-0
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9916
dc.identifier.volume67en_US
dc.identifier.wosWOS:000347948200012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEssential hypertensionen_US
dc.subjectMMP-9en_US
dc.subjectMMP-9 C1562T polymorphismen_US
dc.subjectMTHFRen_US
dc.subjectMTHFR C677T polymorphismen_US
dc.titleIs there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension?en_US
dc.typeArticleen_US

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