Possible role of endocannabinoids in olfactory and taste dysfunctions in Alzheimer's and Parkinson's patients and volumetric changes in the brain

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dc.authoridPETEKKAYA, EMINE/0000-0002-5366-2425
dc.contributor.authorPetekkaya, Emine
dc.contributor.authorKus, Berna
dc.contributor.authorDogan, Serdar
dc.contributor.authorBayarogullari, Hanifi
dc.contributor.authorMutlu, Turay
dc.contributor.authorMelek, Ismet Murat
dc.contributor.authorArpaci, Abdullah
dc.date.accessioned2024-09-18T20:52:51Z
dc.date.available2024-09-18T20:52:51Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe purpose of this study is to determine the volumes of primary brain regions associated with smell and taste in Alzheimer's and Parkinson's patients and healthy controls using MR imaging and examine volumetric changes in comparison to smell/taste questionnaire and test results and endocannabinoid (EC) levels. The study included 15 AD patients with mild cognitive dysfunction scored as 18 <= MMSE <= 23, 15 PD patients with scores of 18 < MoCA < 26 and 18 <= MMSE <= 23, and 15 healthy controls. A taste and smell questionnaire was given to the participants, and their taste and smell statuses were examined using the Sniffin' Sticks smell identification test and Burghart Taste Strips. EC levels were analyzed in the blood serum samples of the participants using the ELISA method. The volumes of the left olfactory bulb (p = 0.001), left amygdala (p = 0.004), left hippocampus (p = 0.008), and bilateral insula (left p = 0.000, right p = 0.000) were significantly smaller in the Alzheimer's patients than the healthy controls. The volumes of the left olfactory bulb (p = 0.001) and left hippocampus (p = 0.009) were significantly smaller in the Parkinson's patients than the healthy controls. A significant correlation was determined between volume reduction in the left Rolandic operculum cortical region and taste dysfunction. EC levels were significantly higher in both AD (p = 0.000) and PD (p = 0.006) in comparison to the controls. Our results showed that volumetric changes occur in the brain regions associated with smell and taste in Alzheimer's and Parkinson's patients. It was observed that ECs played a role in these volumetric changes and the olfactory and taste dysfunctions of the patients.en_US
dc.description.sponsorshipHatay Mustafa Kemal University Sci-entific Research Projects Coordination Unit [MKU-BAP (21)]en_US
dc.description.sponsorshipFinancial support This work was supported by Hatay Mustafa Kemal University Sci-entific Research Projects Coordination Unit [project number MKU-BAP (21.YL.004) .en_US
dc.identifier.doi10.1016/j.jocn.2022.03.047
dc.identifier.endpage58en_US
dc.identifier.issn0967-5868
dc.identifier.issn1532-2653
dc.identifier.pmid35398594en_US
dc.identifier.scopus2-s2.0-85127684055en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage52en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocn.2022.03.047
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11451
dc.identifier.volume100en_US
dc.identifier.wosWOS:000793361300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOlfactory/taste dysfunctionen_US
dc.subjectSniffin' Sticks testen_US
dc.subjectBurghart taste stripsen_US
dc.subjectNeurodegenerative diseaseen_US
dc.subjectEndocannabinoiden_US
dc.subjectAlzheimer diseaseen_US
dc.subjectParkinson diseaseen_US
dc.titlePossible role of endocannabinoids in olfactory and taste dysfunctions in Alzheimer's and Parkinson's patients and volumetric changes in the brainen_US
dc.typeArticleen_US

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