Effects of lycopene on plasma glucose, insulin levels, oxidative stress, and body weights of streptozotocin-induced diabetic rats

Basit Öğe Kaydı
dc.contributor.authorAydin, Muhsin
dc.contributor.authorCelik, Sefa
dc.date.accessioned2024-09-18T20:53:03Z
dc.date.available2024-09-18T20:53:03Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: To determine possible therapeutic effects of oral lycopene supplementation on plasma insulin levels, lipid peroxidation, blood glucose levels, and the antioxidant defense system of streptozotocin-induced diabetic rats. Materials and methods: Classical biochemical methods were used to determine plasma malondialdehyde (MDA), nitric oxide (NO), glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and glutathione (GSH) levels. Enzyme-linked immunosorbent assay was used to determine plasma insulin levels and reverse transcriptase-polymerase chain reaction was used to determine the levels of brain antioxidant enzymes (SOD, CAT, and GSH-Px). Results: It was found that the diabetes-related increase in blood glucose levels was reduced by supplementation of lycopene over an 8-week period. Plasma NO levels and brain tissue GSH levels were meaningfully reduced in the treatment group compared to the diabetic group. In the hemolysate samples, it was determined that the treatment group's SOD, CAT, and GSH-Px activities significantly increased compared to the diabetic group. In the brain tissue homogenates, CAT and SOD activity did not show a significant change, whereas GSH-Px activity was increased in the treatment group compared to the diabetic group. SOD, CAT, and GSH-Px mRNA transcription levels were suppressed in the diabetic group compared to the control, and this suppression was stopped and increases were significantly induced by the supplementation of lycopene. Conclusion: In this study, the oxidative damage and low insulin levels associated with diabetes were ameliorated with the administration of lycopene. The results of this study indicate that lycopene is an effective nutritional component to alleviate and/or prevent the complications of diabetes, and these findings can be used as a basis for future studies.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [106O819]en_US
dc.description.sponsorshipThis study was done at Mustafa Kemal University and was supported by a grant from the Scientific and Technological Research Council of Turkey (TUBITAK, project no.: 106O819). This article is a summary of Muhsin Aydin's master thesis. We thank Mr Gene D. Herzig (AR/USA) for the English revision.en_US
dc.identifier.doi10.3906/sag-1202-44
dc.identifier.endpage1413en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.scopus2-s2.0-84870756887en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1406en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1202-44
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11556
dc.identifier.volume42en_US
dc.identifier.wosWOS:000321226500008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative stressen_US
dc.subjectlycopeneen_US
dc.subjectantioxidant enzymesen_US
dc.subjectmRNAen_US
dc.subjectdiabetesen_US
dc.titleEffects of lycopene on plasma glucose, insulin levels, oxidative stress, and body weights of streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin / Full Text
Boyut:
88.58 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu